The information contained within the linear sequence of bases (the genome) must be faithfully replicated in each cell cycle, with a balance of constancy and variation taking place over the course of evolution. Recently, it has become clear that additional information important for genetic regulation is contained within the chromatin proteins associated with DNA (the epigenome). Epigenetic infor...

Transcription factor A, mitochondrial (TFAM) is a key player in DNA (mtDNA) transcription and replication [...]

Replication fork arrest is a recognized source of genetic instability, and transcription is one of the most prominent causes of replication impediment. We analyze here the requirement for recombination proteins in Escherichia coli when replication-transcription head-on collisions are induced at a specific site by the inversion of a highly expressed ribosomal operon (rrn). RecBC is the only reco...

The duplication of genetic information (DNA replication) is central to life. Numerous control mechanisms ensure the exact course process during each cell division. Disturbances DNA replication have severe consequences for affected cell, and current models link them cancer development. One most accurate methods studying labelling newly synthesised molecules with halogenated nucleotides, followed...