In this study the physical and thermal properties of baobab (Adansonia digitata) fruit pulp powder which are essential for designing engineering processes, material handling, storage, equipment design and fabrication were determined. The physical properties, namely, mean particle size, bulk density, true density and porosity were determined. Also, angle of repose and coefficient of friction wer...

[1] Mechanistic models for sediment transport on hillslopes are needed for applications ranging from landscape evolution to debris-flow hazards. Progress has been made for soil-mantled landscapes; however, little is known about sediment production and transport in bedrock landscapes that often maintain a patchy soil mantle, even though slopes exceed the angle of repose. Herein we investigate th...

Purpose: To prepare and evaluate colon specific drug delivery system of diclofenac sodium for highly localized delivery to the colon. Methods: The colon specific drug delivery system was prepared as matrix-type microspheres using Ethyl Cellulose (EC), Cellulose Acetate Phthalate (CAP), and Eudragit L 100-55 by the Solvent Evaporation Method. Microspheres were evaluated for physical properties l...

Flowability - as measured by hopper discharge rate, angle of repose and Carr's index (CI) - of surface modified microcrystalline cellulose granules was investigated experimentally. Three-dimensional simulations of the granule flow were performed, using the discrete element method (DEM), including either sliding and rolling friction or sliding friction and cohesion in the model. Granule surface ...

We calculated topographic gradients over the surface of the Moon at a 25 m baseline using data obtained by the Lunar Orbiter Laser Altimeter (LOLA) instrument onboard the Lunar Reconnaissance Orbiter (LRO) spacecraft. The relative spatial distribution of steep slopes can be reliably obtained, although some technical characteristics of the LOLA dataset preclude statistical studies of slope orien...

BACKGROUND With the increased use of ontologies and ontology mappings in semantically-enabled applications such as ontology-based search and data integration, the issue of detecting and repairing defects in ontologies and ontology mappings has become increasingly important. These defects can lead to wrong or incomplete results for the applications. RESULTS We propose a unified framework for d...

Objective: The aim of this study was to develop a tablet formulation of Wat Pho hypnotic formula, a classical Thai traditional hypnotic drug. In addition, a preformulation study and physical properties of the finished products were investigated to select the best formulation for further study. Methods: Tablets of the six formulations (D1-D6) were prepared by the direct compression method. The p...

Article history: Received on: 09/07/2013 Revised on: 16/09/2013 Accepted on: 03/10/2013 Available online: 31/10/2013 The aim of the study was to develop a formulation of Ticagrelor 90 mg tablets that is equivalent to the reference product using similar excipients to match the in-vitro dissolution profile. A compressed coated tablet was formulated consisting of Ticagrelor and excipients conformi...

The aim of present study were to arrest the problem of content uniformity without the use of harmful organic solvent and to improve ex vivo permeability of captopril, a low dose class III drug as per biological classification system. Eutectic mixture of camphor and menthol was innovatively used in the work. Captopril solution in eutectic mixture was blended with Avicel PH 102 and then the mixtu...

In the present study, novel co-processed superdisintegrants were developed by solvent evaporation method using crospovidone and sodium starch glycolate in different ratios (1:1, 1:2 & 1:3) for use in the fast dissolving tablet formulations. The developed excipients were evaluated for angle of repose, Carr’s index and Hausner’s ratio in comparison with physical mixture of superdisintegrants. The...