MOTIVATION With the advent of relatively affordable high-throughput technologies, DNA sequencing of cancers is now common practice in cancer research projects and will be increasingly used in clinical practice to inform diagnosis and treatment. Somatic (cancer-only) single nucleotide variants (SNVs) are the simplest class of mutation, yet their identification in DNA sequencing data is confounde...

BACKGROUND Sin Nombre virus (SNV) is the primary cause of hantavirus pulmonary syndrome (HPS) in the United States. Although other studies have demonstrated a possible association between neutralizing antibody titers and the severity of HPS, the exact nature of serologic responses and their association with outcomes have not been fully characterized. METHODS We examined immunoglobulin M (IgM)...

We conducted a statewide survey of Oklahoma small mammals to test for antibodies against rodent-borne viral diseases. Four rodent species had antibody to Sin Nombre virus (SNV), the primary causative agent of hantavirus pulmonary syndrome (HPS), and two species had antibody to Whitewater Arroyo virus, an arenavirus associated with human fatalities. The rodent reservoirs for other HPScausing Nor...

Facial harmony is one of the main goals of orthodontic treatment, and it is not always correlated with the attainment of cephalometric objectives. The purpose of this study was to evaluate two groups of subjects presenting a clinically balanced soft tissue profile using cephalometric radiographs. Thirty lateral cephalometric radiographs of white females, divided in two groups, one with excellen...

BACKGROUND Chronic inflammatory rheumatic disorders are associated with excess cardiovascular mortality. This may result from arteriosclerosis following inflammatory damage to the vessel wall by vasculitis. Our hypothesis that vasculitis results in arteriosclerosis by causing vascular endothelial dysfunction was tested in patients with primary systemic necrotizing vasculitis (SNV). METHODS AN...