OBJECTIVE To examine the association between early childhood respiratory disease and the risk of anxiety and depression in adulthood. DESIGN Cohort study. SETTING Providence cohort of the National Collaborative Perinatal Project. PARTICIPANTS Offspring of 1062 mothers selected for follow-up from birth through adulthood. MAIN EXPOSURE Childhood respiratory disease. MAIN OUTCOME MEASURE...

Twenty-nine patients with a neuronopathic or neuropathic disorder were referred for assessment of respiratory insufficiency between 1978 and 1994. Diagnoses included spinal muscular atrophy (6), chronic idiopathic demyelinating neuropathy (4), Vialetto-van Laere syndrome (3), hereditary motor and sensory neuropathy (3) and a miscellaneous group (5). We also describe seven patients with Guillain...

Oxidative phosphorylation, i.e., ATP synthesis by the oxygen-consuming respiratory chain (RC), supplies most organs and tissues with a readily usable energy source, being functional before birth. Consequently, RC deficiencies can theoretically give rise to any symptom, in any organ or tissue, at any age and with any mode of inheritance, because of the twofold genetic origin of RC components (nu...

Cell and tissue damage in respiratory chain disorders have been related to increased production of reactive oxygen species (ROS). We measured telomere lengths in such disorders since ROS have also been implicated with telomere shortening. We investigated whole blood cell DNA of 14 patients with MELAS-related mitochondriopathy and two patients with the LHON-associated G11778A mutation of the mit...

Head retraction in infancy is a physical sign that is usually associated with central nervous system pathology. It is not generally recognised that head retraction can occur as a consequence of respiratory system abnormality, particularly in younger infants. Head retraction may be seen in any respiratory condition where decreased lung compliance or airway obstruction causes increased work of br...

Mitochondrial Respiratory Chain Disorders (MRCD) are a heterogeneous group of disorders that share the involvement of the cellular bioenergetic machinery due to molecular defects affecting the mitochondrial oxidative phosphorylation system (OXPHOS). Clinically, they usually involve multiple tissues although they tend to mainly affect nervous system and skeletal muscle. Cardiological manifestati...

Pulmonary embolism is now known to be a common disorder, but it is often difficult to diagnose, particularly when recurrent embolization gradually leads to the development of obstructive pulmonary hypertension. The abnormalities of pulmonary function produced by emboli have been the subject of several recent reports ; many of these studies, however, have been performed in the acute phase follow...

The June issue of Breathe looks at biomedical engineering in respiratory disorders http://ow.ly/rn7N30c2qvg.