UNLABELLED Human metapneumovirus (HMPV) is a major cause of respiratory disease in infants, the elderly, and immunocompromised individuals worldwide. There is currently no licensed HMPV vaccine. Virus-like particles (VLPs) are an attractive vaccine candidate because they are noninfectious and elicit a neutralizing antibody response. However, studies show that serum neutralizing antibodies are i...

Mucociliary clearance (MCC) is one of the most important nonspecific defense mechanisms of the respiratory tract, and its impairment is a well-documented feature of chronic respiratory diseases, including asthma. In vitro and in vivo data suggest that several inflammatory mediators influence the mucociliary apparatus. Epithelial damage and functional abnormalities have been described in bronchi...

Abstract Background Respiratory failure due to COVID-19 pneumonia is associated with high mortality and may overwhelm health care systems, the surge of patients requiring advanced respiratory support. Shortage intensive unit (ICU) beds required many be treated outside ICU despite severe gas exchange impairment. Helmet an effective interface provide continuous positive airway pressure (CPAP) non...

Introduction: Smoking habit still becomes one of the problems in Indonesia with high number active smokers university students. is causes several conditions respiratory symptoms and risk factor multiple case lung function impairment. This study aimed to examine characteristic its relationship among student Depok, Indonesia. Methods: was a cross-sectional using American Thoracic Society (ATS) qu...

OBJECTIVE To examine a nationally representative sample of US children aged 6 to 16 years old and determine whether there are differences in risk factors and measures of severity between children with different asthma phenotypes. METHODS We analyzed data from the Third National Health and Nutrition Examination Survey. We used questionnaire and skin-prick testing data to separate children into...

Neonates treated for acute respiratory failure experience episodes of hypoxia. The hippocampus, a structure essential for memory, is particularly vulnerable to such insults. Hence, some neonates undergoing treatment for acute respiratory failure might sustain bilateral hippocampal pathology early in life and memory problems later in childhood. We investigated this possibility in a cohort of 40 ...

Measures of respiratory symptoms and function have been studied in two successive generations over a 25 year period, based on a larger original cohort of 15,411 men and women aged 45-64 and a subsequent family study comprising 2298 adult sons and daughters aged 30-59 from 1477 families. Poor respiratory health is a dominant feature of the original cohort, in association with high rates of socio...

BACKGROUND In chronic obstructive pulmonary disease (COPD), body mass index (BMI) is an important predictor of survival. Little is known about the prevalence of malnutrition or longitudinal changes of BMI in patients undergoing noninvasive positive-pressure ventilation (NPPV). METHODS In a cohort study of 141 patients with COPD and severe chronic respiratory failure (mean forced expiratory vo...

INTRODUCTION The Mini-Mental State Examination (MMSE) is a common cognitive screening test, but its utility in identifying impairments in survivors of acute respiratory failure is unclear. The purpose of this study was to evaluate MMSE performance versus a concurrently administered detailed neuropsychological test battery in survivors of acute respiratory failure. METHODS This cross-sectional...

BACKGROUND Spinal muscular atrophy (SMA) affects respiratory muscles, which in addition to progressive scoliosis leads to respiratory impairment. Children with developing scoliosis are usually treated with spinal bracing to delay the progress. AIMS To assess the impact of body position and application of spinal bracing on lung function during tidal breathing in children with SMA. METHODS Lu...