for the Symposium on Innovative Polymers for Controlled Delivery 1 TAILOR-MADE COPOLYMERS FOR RESPONSIVE DRUG DELIVERY NANOSYSTEMS Sébastien Cajot, Christine Jérôme Center for Education and Research on Macromolecules (CERM), University of Liege, B6 Sart tilman, B-4000 Liege, Belgium. e-mail: [email protected] Summary Amphiphilic macromolecules combining a biodegradable and a bioeliminable block...

Glucose-responsive systems that can change their volumes or other properties in response to glucose concentration, show great potential as drug delivery carriers for controlled release of insulin for diabetes therapy or targeted delivery of anticancer drugs for cancer treatment. In this study, we report on a novel type of monodisperse phenylboronic acid (PBA)-based microcapsules for glucose-res...

Metal-organic frameworks (MOFs) are based on metals and organic linkers; they possess large surface areas, suitable pore size shape, wide range of chemical composition, functionalized surface, which enable them for possible applications as delivery vehicles therapeutic agents. The challenges include not only the development new solids but also continuous improvements in formulation processing m...

A myriad of drug delivery systems such as liposomes, micelles, polymers and inorganic nanoparticles (NPs) have been developed for cancer therapy. Very few of them, however, have the ability to integrate multiple functionalities such as specific delivery, high circulation stability, controllable release and good biocompatibility and biodegradability in a single system to improve the therapeutic ...

Boronic acids have been widely investigated for their potential use as glucose sensors in glucose responsive polymeric insulin delivery systems. Interactions between cyclic diols and boronic acids, anchored to polymeric delivery systems, may result in swelling of the delivery system, releasing the drug. In this study, 4-formylphenylboronic acid conjugated chitosan was formulated into insulin co...