RESTLESS legs syndrome (RLS) is characterized by sensory (urge to move, usually associated with legs paresthesia and dysesthesia) and motor (voluntary and involuntary leg movements) symptoms occurring selectively when the individual is at rest, during the evening and night. This neurologic, dopa-responsive condition is common, especially in middle-aged women, yet poorly recognized. Acute exacer...

The FDA approved gabapentin enacarbil in 2011 as the first non-dopaminergic agent for the treatment of restless legs syndrome (RLS) symptoms. Although gabapentin enacarbil is a pro-drug of gabapentin, its pharmacokinetics differ. Absorption of gabapentin enacarbil is more predictable, and inter-patient variability in bioavailability is lower than that of gabapentin. Studies have demonstrated su...

Restless legs is a medical disorder and can be treated Movement disorders have long been an interest of the Editor of Neuropsychiatric Disease and Treatment (Brimblecombe and Pinder 1972). Movement disorders can manifest as slowness or poverty of movement (hypokinesias) or as abnormal involuntary movements (hyperkinesias). Two of the commonest hyperkinesias are essential tremor, which has been ...

The symptoms of restless legs syndrome (RLS) are associated with reductions in patients' quality of life (QoL) and mental heath. Sleep disturbance, which is often the most troublesome symptom of RLS, may have a negative impact on patients' daytime cognitive abilities. Research has established a relationship between the symptoms of RLS and mood symptoms, but causality is unclear. Some studies ha...

Restless Legs Syndrome (RLS) is a common condition associated with many medical illnesses and medications. Psychotropic medications (both antidepressants and antipsychotics) may be causal. There have been over twenty cases of RLS due to Quetiapine but no published case reports linking RLS to Quetiapine XR. We present the case of a woman with previously established Bipolar Disorder who presented...

Sleep disorders, such as obstructive sleep apnoea (OSA) and restless legs syndrome (RLS), are very common. The relative importance of genetic and nongenetic (environmental) influences on the symptomatology of these conditions has not been well studied. This study uses the twin design to examine this by evaluating OSA and RLS symptoms in monozygotic (MZ) and dizygotic (DZ) twins. Six thousand si...

IMPORTANCE Restless legs syndrome (RLS) is a neurological disorder characterized by unpleasant sensations in the legs and a distressing, irresistible urge to move them. We conducted a systematic review to evaluate efficacy, safety, and comparative effectiveness of pharmacologic treatments for primary RLS. EVIDENCE ACQUISITION We included randomized controlled trials (RCTs), published in Engli...

STUDY OBJECTIVE We report the effective use of injected BTX-A to treat refractory restless legs syndrome (RLS). METHODS This is an observational case series of 3 patients meeting the essential diagnostic criteria for RLS whose symptoms were refractory to or who refused oral medication. Areas of maximal discomfort were injected as described below. RESULTS Patient #1, a 58-year-old man with r...

Limited research suggests a relationship between restless legs syndrome and hypertension. We, therefore, assessed the relationship between restless legs syndrome and hypertension among middle-aged women. This is a cross-sectional study including 65 544 women (aged 41-58 years) participating in Nurses' Health Study II. The participants with diabetes mellitus and arthritis were excluded, because ...

This study aimed to assess thermal and mechanical perception and pain thresholds in primary idiopathic restless legs syndrome and secondary restless legs syndrome associated with small fibre neuropathy. Twenty-one patients (age: 53.4 + or - 8.4, n = 3, male) with primary restless legs syndrome and 13 patients (age: 63.0 + or - 8.2, n = 1, male) with secondary restless legs syndrome associated w...