نتایج جستجو برای: retinoblastoma
تعداد نتایج: 7252 فیلتر نتایج به سال:
Retinoblastoma accounts for 6% of pediatric malignancies under the age of 5 years in the United States, (Broaddus et al., 2008) and epidemiological data suggest that the incidence is standard across populations (Kivelä, 2009). Despite its rarity, observations about the pathogenesis of this disease have enhanced our understanding of genetic cancer syndromes. Germinal or hereditary cases comprise...
The aim of the present review is to give new insights into the pathogenesis of retinoblastoma, by applying the principles of epigenetics to the study of clinical, epidemiological and biological data concerning the disease. As an emerging new scientific approach linking the genome to the environment, epigenetics, can not only explain the inconsistencies of the mutational (‘two hit’) model in the...
BACKGROUND Ophthalmic artery chemosurgery [OAC, intra-arterial chemotherapy (IAC)] was introduced in 2006 as treatment modality for intraocular retinoblastoma. The purpose of this commentary is to retrospectively review the incidence of metastatic deaths in retinoblastoma patients treated with OAC worldwide over a 10 year period. Retrospective data regarding metastatic deaths was collected from...
October 2005 | Volume 2 | Issue 10 | e332 Retinoblastoma is a rare childhood cancer of the retina. Approximately one in 20,000 children are affected worldwide; only 250 to 300 new cases are reported in the United States each year. Enucleation (see Glossary) is usually the treatment of choice for children with unilateral disease. Treatment of children with bilateral retinoblastoma is more challe...
We created a rabbit model of retinoblastoma and confirmed the tumor clinically and histopathologically. Seventeen New Zealand rabbits were immunosuppressed with cyclosporin A at doses of 10-15 mg/kg. At day 3, the animals received a 30 μl subretinal injection of 1 x 10⁶ cultured WERI retinoblastoma cells. Digital fundus images were captured before euthanasia, and the eyes were submitted for his...
Human embryonic stem cells (hESCs) provide a platform for studying human development and understanding mechanisms underlying diseases. Retinoblastoma-1 (RB1) is a key regulator of cell cycling, of which biallelic inactivation initiates retinoblastoma, the most common congenital intraocular malignancy. We developed a model to study the role of RB1 in early development and tumor formation by gene...
Retinoblastoma is the most common primary intraocular tumour of childhood. Though congenital, it is not diagnosed at birth, and is usually seen between 1-2 years of age. We here report a case of bilateral retinoblastoma with early presentation at the age of one month.
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