نتایج جستجو برای: retinoic acid

تعداد نتایج: 747591  

Journal: :Investigative ophthalmology & visual science 2006
Tongalp H Tezel Lijun Geng Henry J Kaplan Lucian V Del Priore

PURPOSE To determine whether retinoids are capable of inducing vascular endothelial cell apoptosis and whether the presence of an intact RPE monolayer can block retinoid-induced vascular endothelial cell death. METHODS Confluent fetal bovine aortic endothelial (FBAE) cells were incubated with various concentrations of all-trans or 9-cis retinoic acid (an analogue of 11-cis retinoic acid). Apo...

Journal: :Experimental eye research 2000
J R Mertz J Wallman

Research over the past two decades has shown that the growth of young eyes is guided by vision. If near- or far-sightedness is artificially imposed by spectacle lenses, eyes of primates and chicks compensate by changing their rate of elongation, thereby growing back to the pre-lens optical condition. Little is known about what chemical signals might mediate between visual effects on the retina ...

2014
Kristin M. Obrochta Maureen A. Kane Joseph L. Napoli

The relationship between dietary vitamin A and all-trans-retinoic acid levels in serum and tissues had not been quantified. We determined the impact of dietary vitamin A on retinoid levels in serum, liver, kidney, testis, and epididymal white adipose of five mouse strains: AKR/J; BALB/cByJ; C3H/HeJ; C57BL/6J; 129S1/SvImJ. Retinoids were quantified in mice fed copious vitamin A (lab chow, ≥20 IU...

Journal: :Cancer research 1995
D R Shalinsky E D Bischoff M L Gregory M M Gottardis J S Hayes W W Lamph R A Heyman M A Shirley T A Cooke P J Davies

Retinoids are promising agents for therapy of squamous cancers. In vitro, retinoids decrease expression of differentiation markers in head and neck squamous carcinoma cells. Little information is available on effects of retinoids on head and neck squamous carcinoma cell xenograft growth in vivo. To address this issue, head and neck squamous carcinoma cells (line 1483) were established as xenogr...

2006
Victoria L. Stevens Nancy E. Owens Elliott F. Winton Joseph M. Kinkade Alfred H. Merrill

The human cell line HL-60 was used to investigate the role of protein kinase C in the regulation of retinole acid-induced maturation of promyelocytic leukemia cells by growth and differentiation factors found in serum. Cells grown in serum-containing medium differentiated less than cells in serum-free medium due to several factors, including albumin binding of retinoic acid. Addition of an inhi...

Journal: :iranian journal of basic medical sciences 0
mohammad miryounesi department of medical genetics, school of medicine, tehran university of medical sciences, tehran, iran karim nayernia geneocell, advanced molecular & cellular technologies, montreal, canada mahdi dianatpour department of medical genetics, school of medicine, shiraz university of medical sciences, shiraz, iran fatemeh mansouri department of medical genetics, school of medicine, tehran university of medical sciences, tehran, iran mohammad hossein modarressi* department of medical genetics, school of medicine, tehran university of medical sciences, tehran, iran

objective(s): sertoli cells support in vivo germ cell production; but, its exact mechanism has not been well understood. the present study was designed to analyze the effect of sertoli cells in differentiation of mouse embryonic stem cells (mescs) to germ cells.   materials and methods: a fusion construct composed of a stra8 gene promoter and the coding region of enhanced green fluorescence pro...

Journal: :Journal of lipid research 1980
A C Ross N Adachi D S Goodman

This study reports the isolation and partial characterization of a soluble protein with binding specificity for retinoic acid from rat testis cytosol. Cytosol, labeled in vitro by incubation with [14C]retinoic acid, was fractionated by a series of procedures that included ion exchange chromatography on DEAE-Sepharose and on DEAE-cellulose, gel filtration on Sephadex (G-50, and preparative polya...

Journal: :Development 1993
M W Kelley X M Xu M A Wagner M E Warchol J T Corwin

The mammalian organ of Corti has one of the most highly ordered patterns of cells in any vertebrate sensory epithelium. A single row of inner hair cells and three or four rows of outer hair cells extend along its length. The factors that regulate the formation of this strict pattern are unknown. In order to determine whether retinoic acid plays a role during the development of the organ of Cort...

Journal: :Cancer research 1980
P W Trown A V Palleroni O Bohoslawec B N Richelo J M Halpern N Gizzi R Geiger C Lewinski L J Machlin A Jetten M E Jetten

A new rapid assay has been developed for measurement of the binding of [3H]retinoic acid to cellular retinoic acid-binding protein. The assay, which uses activated charcoal for the separation of bound from unbound retinoic acid, was used to determine the concentration required to inhibit the binding of [3H]retinoic acid to cellular retinoic acid-binding protein by 50% for 18 retinoids with free...

2006
Hitoshi Ueda Mayumi Ono Yoshiaki Hagino Michihiko Kuwano

After ethyl methane sulfonate mutagenesis of the mammary carcinoma cell line, MCF-7, we have isolated three clones, U-2, U-3, and U-9, resistant to retinole acid. These three clones showed more than a 1000-fold higher level of resistance to retinoic acid than the parental MCF-7 cells when assayed by colony formation in monolayer culture system or by growth curves. The three resistant clones sho...

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