By J. PHILIP SAVITSKY, M.D. C HANGES in platelet adhesivemiess have been noted during the course of many different clinical conditions.t4 Imicreased platelet adhesiveness has been correlated by some investigators with a predisposition to thromboembolic phemiomena and vascular disease,2 but other work has not confirmed this suiggestion.3 It has been show’mi that there is a very close relation be...

Retraction artifacts are well known phenomenon in diagnostic surgical pathology for a long time but they were usually considered as artificially produced tissue alteration. Some recent studies of retraction artifact in different tumors have focused on its diagnostic and/or prognostic role. Their presence in prostatic carcinoma may be used in diagnostic and prognostic purposes. Peritumoral retra...

Filopodia are thin cell extensions sensing the environment. They play an essential role during cell migration, cell-cell or cell-matrix adhesion, by initiating contacts and conveying signals to the cell cortex. Pathogenic microorganisms can hijack filopodia to invade cells by inducing their retraction towards the cell body. Because their dynamics depend on a discrete number of actin filaments, ...

Growth cone motility and guidance depend on the dynamic reorganization of filamentous actin (F-actin). In the growth cone, F-actin undergoes turnover, which is the exchange of actin subunits from existing filaments. However, the function of F-actin turnover is not clear. We used jasplakinolide (jasp), a cell-permeable macrocyclic peptide that inhibits F-actin turnover, to study the role of F-ac...

BACKGROUND Alar retraction is a challenging condition in rhinoplasty marked by exaggerated nostril exposure and awkwardness. Although various methods for correcting alar retraction have been introduced, none is without drawbacks. Herein, we report a simple procedure that is both effective and safe for correcting alar retraction using only conchal cartilage grafting. METHODS Between August 200...

Type IV pilus (T4P) systems are complex molecular machines that polymerize major pilin proteins into thin filaments displayed on bacterial surfaces. Pilus functions require rapid extension and depolymerization of the pilus, powered by the assembly and retraction ATPases, respectively. A set of low abundance minor pilins influences pilus dynamics by unknown mechanisms. The Vibrio cholerae toxin-...

Brain retraction and induced hypotension are surgical adjuncts capable of compromising cerebral blood flow. To evaluate their effects upon brain function, cortical evoked potentials, neurological status and cortical histological changes were determined as a function of graded levels of brain retractor and systemic perfusion pressure in the dog. Somatosensory evoked potentials recorded from the ...

Platelet facilitation of clot lysis was studied using the dilute clot lysis assay, a standardized assay for fibrinolysis shown to correlate with the development of postoperative deep vein thrombosis. Clots prepared from dilute platelet poor plasma showed prolonged clot lysis when compared with clots prepared in a similar fashion from dilute platelet rich plasma. Since in the presence of platele...

The purpose of this study was to clinically assess the precision of margins reproduction using some impression techniques following application of different retraction materials. A PVS impression material with different viscosities and an injectable tissue retraction material were chosen to make impression using two impression techniques. Traditional retraction cord was used as a control. A num...

BACKGROUND Laparoscopic bariatric surgery requires retraction of the left lobe of the liver to provide adequate operative view and working space. Conventional approaches utilize a mechanical retractor and require additional incision(s), and at times an assistant. OBJECTIVES This study evaluated the safety and efficacy of a suture-based method of liver retraction in a large series of patients ...