(R)-Bgugaine is a natural pyrrolidine alkaloid from Arisarum vulgare, which shows antifungal and antibacterial activity. In this Letter, we have accomplished the simple synthesis of norbgugaine (demethylated form of natural bgugaine) employing Wittig olefination and cat. hydrogenation as the key steps and its biological studies are reported for the first time. The synthesized norbgugaine was ev...

Background/Aim: A number of biologically active substances were proved as an alternative to conventional anticancer medicines. The aim the study is in vitro investigation activity mono- and di-Rhamnolipids (RL-1 RL-2) against human breast cancer. Additionally, combination with Cisplatin was analyzed. Materials Methods: Breast cell lines (MCF-10A, MCF-7 MDA-MB-231) treated RLs Cisplatin. viabili...