Mutations in the human Tsc1 and Tsc2 genes predispose to tuberous sclerosis complex (TSC), a disorder characterized by the wide spread of benign tumors. Tsc1 and Tsc2 proteins form a complex and serve as a GTPase-activating protein (GAP) for Rheb, a GTPase regulating a downstream kinase, mTOR. The genome of Schizosaccharomyces pombe contains tsc1 and tsc2, homologs of human Tsc1 and Tsc2, respe...

Andes virus (ANDV) predominantly infects microvascular endothelial cells (MECs) and nonlytically causes an acute pulmonary edema termed hantavirus pulmonary syndrome (HPS). In HPS patients, virtually every pulmonary MEC is infected, MECs are enlarged, and infection results in vascular leakage and highly lethal pulmonary edema. We observed that MECs infected with the ANDV hantavirus or expressin...

T arget of rapamycin complex 1 (TORC1) is an evolutionarily conserved regulator of cell growth and metabolism. It integrates multiple inputs (hormones, growth factors, amino acids, and cellular energy) to activate anabolic processes such as protein, lipid, and nucleotide synthesis, and to inhibit catabolic processes including autophagy. Inputs impinge on TORC1 via the TSC complex (composed of t...