Five syngeneic transplants were performed in four patients following myeloablative therapy using unmodified peripheral blood mononuclear cells (PBMCs) collected after the administration of recombinant human granulocyte colony stimulating factor (rhG-CSF) to normal donors. The only toxicity experienced by the four normal donors was bone pain. Four patients received two collections of PBMCs, and ...

phadenopathy. Laboratory studies revealed a hematocrit of 18.3%, platelet count 118000/mm3, and leukocyte count of 5200/mm3 with 81% lymphoblasts, 1% myelocytes, 4% neutrophils and 14% lymphocytes. The bone marrow smear showed 95% blast cells. Intravenous piperacillin and gentamicin therapy was started on an empirical basis. After 10 days without response to the antibiotic regimen, he received ...

Forty six patients with lymphoid malignancies receiving autologous transplants using three different sources of hematopoietic stem cells were compared for engraftment parameters. Thirteen patients (five with multiple myeloma, seven with non-Hodgkin's lymphoma and one with Hodgkin's lymphoma) received autologous marrow with post-transplant growth factors (group 1). During the same time interval,...

In Drosophila subperineurial glia (SPG) ensheath and insulate the nerve. SPG is under strict cell cycle and survival control because cell division or death of such a cell type would compromise the integrity of the blood-nerve barrier. The mechanisms underlying the survival of SPG remain unknown. Here, we show that the embryonic peripheral glia expresses the Zfh1 transcription factor, and in zfh...

Peripheral blood stem cells (PBSCs) are widely used in autologous transplantation because of ease of collection and rapid hematopoietic reconstitution. However, PBSCs have rarely been used for allogeneic transplantation because of concerns about donor toxicities from cytokine administration and the theoretical increased risk of graft-versus-hostdisease (GVHD) from the large number of T cells in...

Recombinant human granulocyte colony-stimulating factor (rhG-CSF) induces leukocytosis in vivo in both intact and splenectomized mice. Full dose response data showed a plateau in this effect at doses over 500 micrograms rhG-CSF/kg body weight/d in intact mice. The effect is magnified in splenectomized mice, where leukocyte numbers reach 100 x 10(6) mL after 4 days' treatment at 250 micrograms/k...

T h e n u m b e r o f resistance genes in soybean to soybean cyst nematode (SCN) Heterodera glycines was est imated using progeny f rom a cross of 'Williams 82' x 'Hartwig' (derived f rom 'Forrest '~ x PI 437.654) screened with a four th-genera t ion inbred nematode line der ived f rom a race 3 field popula t ion o f SCN. Numbers o f females developing on roots o f inoculated seedlings were ass...

The purpose of this study was to investigate whether cinnabar causes renal inflammation and fibrosis in rats. Rats were dosed orally with cinnabar (1 g/kg/day) for 8 weeks or 12 weeks. The control rats were treated with solvent (5% carboxymethylcellulose solution) over the same time periods, respectively. Renal mercury (RHg), urinary mercury (UHg), serum creatinine (SCr), urine kidney injury mo...

Concurrent chemoradiotherapy (CCRT) is an important treatment modality for malignancies.1, 2 Neutropenia the most common hematological toxicity of CCRT and can often lead to febrile neutropenia (FN), toxic shock, even death, which not only seriously impact clinical survival cancer patients, but also increase their medical expenses.3-5 Numerous national international organizations have published...