نتایج جستجو برای: rhodopsin
تعداد نتایج: 4793 فیلتر نتایج به سال:
Molecular Mechanisms Oliver P. Ernst,*,† David T. Lodowski,‡ Marcus Elstner, Peter Hegemann, Leonid S. Brown, and Hideki Kandori †Departments of Biochemistry and Molecular Genetics, University of Toronto, 1 King’s College Circle, Medical Sciences Building, Toronto, Ontario M5S 1A8, Canada ‡Center for Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, 10900 Euclid...
Cattle rhodopsin can be highly oriented by shearing a wet paste of digitonin micelles of this visual pigment between two quartz slides. This orients the rhodopsin micelles so that their chromophores lie mainly parallel to the direction of shear. In such preparations the orientation of rhodopsin and intermediates of its bleaching by light have been measured with plane-polarized light from -195 d...
Rhodopsins are the members of the family of G protein-coupled receptors that have diverged from ligand-binding receptors into photoreceptive pigments. Vertebrate rhodopsins are able to bind the inverse agonist 11-cis-retinal but are unable to bind the agonist all-trans-retinal, indicating that vertebrate rhodopsin changed its binding ability during the course of molecular evolution. Here, we sh...
Phosphorylation of activated G-protein-coupled receptors and the subsequent binding of arrestin mark major molecular events of homologous desensitization. In the visual system, interactions between arrestin and the phosphorylated rhodopsin are pivotal for proper termination of visual signals. By using high resolution proton nuclear magnetic resonance spectroscopy of the phosphorylated C terminu...
The developmental pattern of rhodopsin phosphorylation in degenerative (rdle homozygote) and normal (rd/+ heterozygote) mouse retina has been investigated. The results indicate that rhodopsin levels are comparable in the 2 retinas up to about 10 days of age but that rhodopsin phosphorylation is not. The phosphorylation of rhodopsin is substantially reduced in the degenerative retina during deve...
Protein misfolding caused by inherited mutations leads to loss of protein function and potentially toxic 'gain of function', such as the dominant P23H rhodopsin mutation that causes retinitis pigmentosa (RP). Here, we tested whether the AMPK activator metformin could affect the P23H rhodopsin synthesis and folding. In cell models, metformin treatment improved P23H rhodopsin folding and traffic....
چکید ه سابقه و هدف سلولهای بنیادی CD133+ بند ناف، زیر گروهی از سلولهای خونساز را تشکیل میدهند. ثابت شده که این سلولها از توانایی تمایز خوبی به سمت سلولهای عصبی برخوردار هستند. ژن PAX6 جزیی از خانواده چند ژنی PAX و از فاکتورهای رونویسی است. ژن PAX6 ژن کنترلکننده اصلی تکامل چشم و اندامهای حسی بافتهای اپیدرمی و عصبی میباشد. هدف از این مطالعه، بررسی روند تمایزی سلولهای CD133+ به د...
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