PURPOSE To determine intraoperative changes in corneal thickness and outcomes of corneal collagen crosslinking (CXL) using 2 intraoperative regimens: riboflavin-dextran or hypotonic riboflavin. SETTING Cornea and refractive surgery practice, Teaneck, New Jersey, USA. DESIGN Prospective randomized case series. METHODS Eyes with keratoconus or corneal ectasia were treated. All eyes received...

1. Riboflavin deficiency at two levels of severity was produced in weanling rats by feeding deficient diets for 6 weeks and using neck collars to prevent coprophagy. The severity of deficiency was monitored by growth, liver flavin levels and the activation coefficient of erythrocyte glutathione oxidoreductase (NAD(P)H) (EC 1.6.4.2). Control groups, receiving the same diet with ample added ribof...

Riboflavin is the precursor of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), coenzymes required for the activity of flavoenzymes involved in the transfer of electrons in oxidation-reduction reactions. Flavins are light sensitive and rapidly degrade when exposed to light in the near ultraviolet and visible wavelengths. Some of the byproducts of flavin photodegradation are to...

Background Riboflavin (vitamin B2) is an essential component of the basic metabolism, and an important nutritional and growth factor in humans, animals, plants and micro-organisms. It has been widely used in the fields of pharmaceuticals, feed and food additives. The industrial production of riboflavin mostly relies on the microbial fermentation. Designing an appropriate fermentation medium is ...

Flavin nucleotides are components of certain enzyme systems which are involved in the oxidation of nitrogenous compounds, including at least some of the amino acids. The oldest and best-known evidence for this relationship was derived from studies of biochemical systems in vitro, but it is also supported by the results of studies on intact animals. For example, Burch, Lowry, Padilla & Combs (19...

Man has a limited capacity to absorb riboflavin (1-3) and thiamin (4, 5). The gastrointestinal absorption of these vitamins is describable by Michaelis-Menten type kinetics, characteristic of saturable, specialized absorption processes (6). Both vitamins are phosphorylated in the intestinal mucosa during absorption (7-9) and there is evidence suggesting that this process is the basic mechanism ...

Background: Food insecurity and hunger not only affect physical health, but also have social and psychological effects. Therefore, providing food security for society is one of the major goals of social and economical development programs. The objective of this study was to determine the prevalence and intensity of food insecurity at North West of Tabriz as a population sample of East Azerb...

the adsorption characteristics of riboflavin onto silver-deposited iron oxide magnetic nanoparticles (ag/fe3o4) have been described. characterization of the synthesized ag/fe3o4 nanoparticles was achieved by ftir spectra, tem image and xrd pattern. the influence of several experimental parameters such as nanoparticles dosage, ph of the sample solution, different orientations of the riboflavin m...

The deactivation of triplet excited state riboflavin by polyphenols, e.g. rutin and catechin, was studied on the basis of density functional theory calculations. The results show that the H-atom transfer pathway is more feasible on thermodynamic grounds in comparison with the direct energy transfer or direct electron transfer pathways involved in the triplet excited state riboflavin deactivatio...

Riboflavin (vitamin B2) has been thought to be a promising antitumoral agent in photodynamic therapy, though the further application of the method was limited by the unclear molecular mechanism. Our work reveals that riboflavin was able to recognize G-T mismatch specifically and induce single-strand breaks in duplex DNA targets efficiently under irradiation. In the presence of riboflavin, the p...