Most atypical antipsychotic drugs (APDs), e.g. risperidone (RIS), produce more extensive blockade of brain serotonin (5-HT)(2A) than dopamine (DA) D(2) receptors. This distinguishes them from typical APDs, e.g. haloperidol (HAL). Our objective was to test the hypothesis that augmentation of low doses of RIS or HAL (2mg/day) with pimavanserin (PIM), a selective 5-HT(2A) inverse agonist, to enhan...

Rambouillet crossbred ewe lambs were used to evaluate the effect of repeated restraint and isolation stress (RIS) on endocrinological and immunological functions. Lambs were blocked by weight and assigned to either RIS (n = 6) or to control (CON; n = 6) treatments. All lambs were tethered in environmentally controlled rooms at 22 degrees C with constant light and, at this time (d 0), were given...

Previous research on children’s use of non-finite verb forms in finite contexts -Root Infinitives (RIs) -distinguished two types of the latter: those that describe an on-going activity (“extensional”), and those that are produced in the context of children’s wishes, desires, or intentions (“intensional”). This study provides a syntactic account of children’s intensional RIs. We argue that the a...

In recent magnetoencephalographic studies, we established a novel component of the auditory evoked field, which is elicited by a transition from noise to pitch in the absence of a change in energy. It is referred to as the 'pitch onset response'. To extend our understanding of pitch-related neural activity, we compared transient and sustained auditory evoked fields in response to a 2000-ms segm...

By using an original two-step technique (trioxsalen crosslinking/immunoprecipitation) we were able to isolate in a single-stranded form a fraction of mouse DNA enriched in putative Replication Initiation Sequences (RIS). The isolated and purified single-strand fragments were made double-stranded in vitro and were cloned in pUC12 to prepare a confined RIS library. 30 randomly selected RIS insert...

The combination of secondary neutral mass spectrometry ~SNMS! and resonance ionization spectroscopy ~RIS! has been shown to be a powerful tool for the detection of low levels of elemental impurities in solids. Drawbacks of the technique have been the laser-repetition-rate-limited, low duty cycle of the analysis and the fact that RIS schemes are limited to determinations of a single element. The...

The responses of the Ross Ice Shelf (RIS) to the 16 September 2015 8.3 (Mw) Chilean earthquake tsunami (>75 s period) and to oceanic infragravity (IG) waves (50–300 s period) were recorded by a broadband seismic array deployed on the RIS from November 2014 to November 2016. Here we show that tsunami and IG-generated signals within the RIS propagate at gravity wave speeds ( 70 m/s) as water-ice ...

PURPOSE Cerebrovascular events (CVE) are the third most common cause of death in Western countries and about 65-70% of CVE are due to atherosclerotic disease of carotid arteries. Color Doppler scanning is used to evaluate the presence, severity and type of atheromatous plaques as well as velocity parameters of carotid arteries. We performed this study to correlate data of morphological and velo...

The function of lymphocytes is the key to reflect the immune status of hosts. Evaluation of lymphocyte function is a useful tool to monitor the effect of immunosuppressive treatment and predict the prognosis of immune-mediated diseases (e.g., cancer, autoimmune diseases, and infectious diseases). As the lymphocytes have various activities, such as activation, cytotoxicity, and cytokine secretio...

We have previously demonstrated, using in vitro assays, a high degree of selective binding of monoclonal antibody (MAb) B72.3 for carcinomas of the colon, ovary, and breast versus normal adult tissues using in vitro assays. We report here a demonstration of selective tumor localization in colorectal cancer patients of i.v. administered 131I-labeled MAb B72.3 immunoglobulin G prior to surgery. R...