Keratoconus has usually been described as bilateral but asymmetric disease. Corneal ectasia is one of the long-term complications of modern refractive surgery, especially those submitted to laser in situ keratomileusis (LASIK). We describe a patient with keratoconus in the right eye that was submitted to radial keratectomy (RK) in the left eye 19 years ago with no progression of the ectatic cor...

RK-682 was reported to be a potent protein tyrosine phosphatase inhibitor. We found that (R)-3-hexadecanoyl-5-hydroxymethyltetronic acid (1) was easily converted to its calcium salt during column chromatography on Silica gel 60, and this calcium salt was identical to RK-682 originally isolated from a natural source. Here we report details of the asymmetric synthesis of (R)-1 and its conversion ...

We report the case of a 46-year-old female patient who was referred to our clinic (Orasis Eye Clinic, Reinach, Switzerland) seeking improvement of her distance and near visual acuity. Radial keratotomy (RK) was performed at a younger age on both eyes to correct -5 D myopia. The patient underwent a bilateral same-session multifocal corneal excimer femtosecond laser (Supracor) keratomileusis corr...

An iterative method LSMR is presented for solving linear systems Ax = b and leastsquares problems min ‖Ax−b‖2, with A being sparse or a fast linear operator. LSMR is based on the Golub-Kahan bidiagonalization process. It is analytically equivalent to the MINRES method applied to the normal equation ATAx = ATb, so that the quantities ‖Ark‖ are monotonically decreasing (where rk = b−Axk is the re...

A novel family of exponential Runge-Kutta (expRK) methods are designed incorporating the stable steady-state structure of genetic regulatory systems. A natural and convenient approach to constructing new expRK methods on the base of traditional RK methods is provided. In the numerical integration of the one-gene, two-gene, and p53-mdm2 regulatory systems, the new expRK methods are shown to be m...

— We discuss the NA62 experiment which aims at the search for phenomena beyond the Standard Model (SM) by measuring the ratio RK = Γ(K ± → eν(γ))/Γ(K → μν(γ)) and the ultra rare decay K → πνν. First, we summarize the status of the RK analysis, based on ∼ 40% of the 2007-2008 NA62 data set, then, we describe the NA62 proposal to measure the branching ratio of the very rare decay K → πνν and we g...

The linear differential operator with constant coefficients D(y)=y(n)+a1y(n−1)+…+any,y∈Cn(R,X) acting in a Banach space X is Ulam stable if and only its characteristic equation has no roots on the imaginary axis. We prove that of D distinct rk satisfying Rerk>0,1≤k≤n, then best KD=1|V|∫0∞|∑k=1n(−1)kVke−rkx|dx, where V=V(r1,r2,…,rn) Vk=V(r1,…,rk−1,rk+1,…,rn),1≤k≤n, are Vandermonde determinants.

SABIO-RK (http://sabio.h-its.org/) is a web-accessible database storing comprehensive information about biochemical reactions and their kinetic properties. SABIO-RK offers standardized data manually extracted from the literature and data directly submitted from lab experiments. The database content includes kinetic parameters in relation to biochemical reactions and their biological sources wit...

RFID-based tag matching allows a reader Rk to determine whether two tags Ti and Tj store some attributes that jointly fulfill a boolean constraint. The challenge in designing a matching mechanism is tag privacy. While cheap tags are unable to perform any computation, matching has to be achieved without revealing the tags’ attributes. In this paper, we present T-MATCH, a protocol for secure and ...