We developed several novel tools to genome wide screen for CNVs and SNPs in single cells. When applied to cleavage stage embryos from young fertile couples we discovered, unexpectedly, an extremely high incidence of chromosomal instability, a hallmark of tumorigenesis (Vanneste et al., Nature Medicine, 2009; Vanneste et al., Hum.Reprod., 2011). Not only mosaicisms for whole chromosome aneuploid...

AIMS To determine levels of systemic disease among cases of death due to opioid toxicity. DESIGN Analysis of coronial cases. SETTING Sydney, Australia. CASES A total of 841 cases of death due to opioid toxicity (1 January 1998-31 December 2002). FINDINGS Ventricular hypertrophy was present in 5.9% of cases and severe coronary artery atherosclerosis in 5.7%. Severe coronary pathology was...