نتایج جستجو برای: rs9939609 polymorphism
تعداد نتایج: 107470 فیلتر نتایج به سال:
Aim of the study was to investigate association polymorphisms some genes with overweight and certain anthropometric biochemical parameters in a population sample adolescents Novosibirsk. Material methods. In 2019, population-based screening representative (609 people) carried out All children their parents signed an informed consent for examination. The approved by local Ethics Committee Resear...
AIMS Mendelian randomization uses genetic variants related to environmentally modifiable risk factors in an attempt to improve causal inference from observational data. We examined the effect of lifetime body mass index (BMI) on adult carotid intima-media thickness (CIMT) and various atherosclerotic risk factors by using both Mendelian randomization and conventional analyses. METHODS AND RESU...
The association between variation in the fat mass and obesity-associated (FTO) gene and adulthood body mass index (BMI; weight (kg)/height (m)(2)) is well-replicated. More thorough analyses utilizing phenotypic data over the life course may deepen our understanding of the development of BMI and thus help in the prevention of obesity. The authors used a structural equation modeling approach to e...
BACKGROUND A common single nucleotide polymorphism (SNP) of FTO (rs9939609, T/A) is associated with total body fatness. We investigated the association of this SNP with abdominal and peripheral fatness and obesity-related metabolic traits in middle-aged men through a broad range of fatness present already in adolescence. METHODOLOGY/PRINCIPAL FINDINGS Obese young Danish men (n = 753, BMI > or...
CONTEXT Polymorphisms within the FTO gene have consistently been associated with obesity across multiple populations. However, to date, it is not known whether the association between genetic variation in FTO and obesity is mediated through effects on energy intake or energy expenditure. OBJECTIVE Our objective was to examine the association between alleles of FTO known to increase obesity ri...
Recent genome wide association studies identified many loci in several genes that have been consistently associated with type 2 diabetes mellitus in various ethnic populations. Among the genes that were most strongly associated with diabetes were fat mass- and obesity-associated, melanocortin 4 receptor, solute carrier family 30 member 8 (SLC30A8), and a member of the potassium voltage-gated ch...
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