New Cancer Therapies for the 21st Century: A Two Decade Review of Approved Drugs and Drugs in Development in the United States Erlinda M. Gordon1,2*, Neal S. Chawla1 , Frederick L. Hall2, Sant P. Chawla1 1Cancer Center of Southern California/Sarcoma Oncology Center, Santa Monica CA 90403 2Counterpoint Biomedica LLC, Santa Monica, CA 90405 *Corresponding author: Dr. Erlinda M. Gordon, M.D. , Dir...

The alkaline phosphatase activities of 6-thiopurine-sensitive and -resistant sublines of Sarcoma 180 were exam ined in a further study of these enzymes, which have a role in the resistance of Sarcoma 180/TG to 6-thioguanine and 6-mercaptopurine. Both neoplasms possessed particulate-bound alkaline phosphatase enzymes labeled A and B on the basis of their ease of solubilization from the particula...

Primary sarcoma tumours of the prostate are rare and are classified, according to their histology, as stromal tumours of uncertain malignant potential (STUMP) and stromal prostatic sarcoma (PS; low and high grade). We describe a case of a 71-year-old man that developed progressive urinary obstruction symptoms and was subjected to a transurethral prostatic resection (TURP). Histologically, there...

Interdigitating dendritic cell sarcoma is extremely rare neoplasm that mainly occurs in the lymph nodes. Only 45 cases have been reported in the literature to date. We report a case of this sarcoma arising from the liver and lung, a previosly unreported site for this neoplasm. An 19-year-old girl deteriorated rapidly after artificial abortion and died 4 weeks later. Autopsy showed markedly enla...

UNLABELLED Mammary sarcoma is extremely rare and the diagnosis is established only after metaplastic carcinomas and malignant phyllodes tumours are excluded. A rare case of not otherwise specified-type sarcoma with CD10 expression in the left breast in a 45-year-old female was presented. It was a high-grade tumour composed of spindle cells histologically. The immunohistochemical results showed ...

Histiocytic sarcoma (HS) is a rare malignant neoplasia of hematopoietic origin and unknown etiology. We studied three patients with histiocytic sarcoma reviewing the morphological and immunohistochemical aspects. We evaluated in particular, if apoptosis may be unbalanced in this disease. All cases have morphological and immunohistochemical features consistent with the diagnosis of histiocytic s...

sarcomas account for less than 1% of all primary breast malignancies, pleomorphic sarcoma of the breast being even rarer. we present two cases of pleomorphic sarcoma of the breast in a 35-year-old and a 43-year-old female. an extensive review of the available literature with evaluation of the etiology, changing terminologies and histopathologic features of pleomorphic sarcoma of the breast are ...

An analysis of cell cycle-dependent expression of tumor-associated antigen was performed on a human neurosarcoma cell line (T2 cells). The expression of sarcoma-associated tumor antigen on T2 cells was detected using test sera obtained from sarcoma patients; control sera were from patients with nonsarcoma neoplasias and from normal donors. Results indicate a progressive increase in the antigeni...

8. Koizumi H, Kumakiri M, Ishizuka M, Ohkawara A, Okabe S. Leukaemia cutis in acute myelomonocytic leukaemia: infiltration of minor traumas and scars. J Dermatol. 1991;18:281--5. 9. Kristensen IB, Moller H, Kjaershov MW, Yderstraede K, Moller MB, Bergmann OJ. Myeloid sarcoma developing in pre-existing pyoderma gangrenoso. Acta Derm Venereol. 2009;89:175--7. 10. Guinovart RM, Carrascosa JM, Ferr...