Many regularization schemes for high-dimensional regression have been put forward. Most require the choice of a tuning parameter, using model selection criteria or cross-validation. We show that a simple sign-constrained least squares estimation is a very simple and effective regularization technique for a certain class of high-dimensional regression problems. The sign constraint has to be deri...

Hearing someone refer to themselves in the third person may seem "wacky", but you may be surprised to learn that it can actually be pretty helpful to the person doing it. Some people find that speaking in third person improves their self-esteem, their ability to perform well under stress, to manage their emotions more favorably, and to think through complex situations in a more rational and cal...

Hearing someone refer to themselves in the third person may seem "wacky", but you may be surprised to learn that it can actually be pretty helpful to the person doing it. Some people find that speaking in third person improves their self-esteem, their ability to perform well under stress, to manage their emotions more favorably, and to think through complex situations in a more rational and cal...

SIGN-R1 is a principal receptor for microbial polysaccharides uptake and is responsible for C3 fixation via an unusual complement activation pathway on splenic marginal zone macrophages. In these macrophages, SIGN-R1 is also involved in anti-inflammatory activity of intravenous immunoglobulin by direct interaction with sialylated Fcs. The high-resolution crystal structures of SIGN-R1 carbohydra...

~. The api~roach out1~ed below is to be understood as a component of a more general method of semantic interpretation of natural languages, Roughly spea~.ing th~s method (develor~.e6 in my forthcoming Elements of a Sem~.ntic Theor~r of }T~tur~J Lan6u~es) might be characterized , as fol].ows: I °. A semantic ~ystcm S in a very generP.] form (like that of Carn~p's 'Language A' or 'L~n:~e~ b ,-o-~...

Natural selection is an important factor influencing variation in the human genome, but most genetic studies of natural selection have focused on variants with unknown phenotypic associations. This trend is changing. New studies are rapidly revealing the effects of natural selection on genetic variants of known or likely functional importance.

On ly recen tly h as it becom e common to determ in e eukaryotic gen om ic sequen ces large en ough to con tain several gen es. With th ese data com es a n ew problem for gen e fin din g program s: to partit ion a set of exon s correctly am on g several gen es. On e lin e of developm en t in eukaryot ic gen e iden tification begin s with codin g region iden tificat ion by statist ical m ean s a...

Lithium is one of the simplest metals, with negative charge carriers and a close reproduction of free-electron dispersion. Experimentally, however, Li is one of a handful of elemental solids (along with Cu, Ag, and Au) where the sign of the Seebeck coefficient (S) is opposite to that of the carrier. This counterintuitive behavior still lacks a satisfactory interpretation. We calculate S fully f...

A survey of reports of sign order from 42 sign languages leads to a handful of generalizations. Two accounts emerge, one amodal and the other modal. We argue that universal pressures are at work with respect to some generalizations, but that pressure from the visual modality is at work with respect to others. Together, these pressures conspire to make all sign languages order their major consti...

UNLABELLED A poorly understood aspect of deaf people (DP) is how their emotional information is processed. Verbal ability is key to improve emotional knowledge in people. Nevertheless, DP are unable to distinguish intonation, intensity, and the rhythm of language due to lack of hearing. Some DP have acquired both lip-reading abilities and sign language, but others have developed only sign langu...