background: transcriptional silencing of tumor suppressor genes and tumor related genes like gstp1 by methylation of promotor region cpg island is believed to be an important mechanism in tumorigenesis. the gstp1 gene encodes the enzyme glutathione s-transferase pi which defends the cells against oxidative damage and electrophilic carcinogens. methods: to gain insight into the role of epigeneti...

Heparin and its derivatives are known to attenuate cancer metastasis in preclinical models, but have not been used clinically due to adverse bleeding effects. This study compared the efficacy of S-NACH (a sulfated non-anticoagulant heparin) versus tinzaparin (a low molecular weight heparin) in inhibiting metastasis of a growing primary tumor and following surgical excision of primary tumor in a...

The modulation of methotrexate polyglutamylation by L-asparaginase has been examined in mice bearing sublines of leukemia L5178Y that have different sensitivities to asparaginase. A single i.p. injection of 200 IU/kg of asparaginase completely inhibited ascites tumor cell growth in the parental L5178Y/S+ tumor for 120 h compared to 72 and 30 h in the L5178Y/S and L5178Y/S+/- sublines, respectiv...

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background: wilms' tumor is an emberyonal tumor arising from remnants of immature renal tissue. her2/neu is an onco-protein which mediates cellular proliferation, differentiation and survival. methods: in the current study, we analyzed her2/neu expression in 40 wilms' tumors. the clinico-demographic data of 40 patients with wilms' tumor were retrieved. immunohistochemical staining for her2/neu ...

the majority of osseous tumors of the hand are benign. the surgeon who evaluates and treats osseous tumors of the hand has to be familiar with limb anatomy, tumor biology, various presentations of the tumors and the range of treatment possibilities and their limitations. lesions in the hand more often present earlier in their course than those at other sites, just because they are more likely t...

Abstract In several cancers, including the aggressive sarcoma, rhabdomyosarcoma (RMS), tumor-associated myeloid cells (TAMCs) are largest immune populations and correlated with poor survival outcomes. TAMCs a mixed ‘plastic’ population that can sense changes in their environment, intra-tumoral ECM stiffness, change functioning accordingly. Despite clinical influences these have detrimental effe...