Herds with recent clinical outbreaks of Salmonella dublin (7 herds) and S. typhimurium (4 herds) infections were followed serologically in O-antigen ELISAs over about one year, divided in four equal sampling phases. Animals found to be persistent high-reactors or seronegative at the end of the study were slaughtered and subsequently cultured for salmonella in a selected number of organ samples....

Previous animal and human studies have shown protective effects of Ca on the resistance to enteropathogenic infections. Most interventions were performed with calcium phosphate and little is known about the protective effect of other dietary sources of Ca. Therefore, we investigated the efficacy of several Ca salts to enhance intestinal resistance to Salmonella enteritidis infection. Rats (n 7-...

Commercial poultry production is ranked among the highest source of animal protein in the world. Microbial infections caused by bacteria (Salmonella, Clostridium perfringes) and parasites particularly Eimeria has continued to challenge the poultry industry. Antibiotic Growth Promoters (AGP) have been traditionally used to counter microbial infections in poultry. But due to public health concern...

Salmonella infection in humans can become chronic, which leads to low-grade persistent inflammation. These chronic infections increase the risk of several gastrointestinal diseases, including cancer. Salmonella AvrA is a multifunctional protein that influences eukaryotic cell pathways by regulating ubiquitination and acetylation. In an animal model, we have demonstrated that infection with AvrA...

In my opinion, the conclusions given in the recent paper published on antimicrobial-resistant Salmonella in your Journal [1] are erroneous and opposite to what emerges from any objective analysis of the data. In contrast to their conclusions, there seems an obvious and clear association between antibiotic-resistant Salmonella isolates in animal and human ones. Their major antibiotic resistance ...

Laboratory-acquired infections concern all microbiologists. During ongoing surveillance of laboratory-acquired enteric infections, salmonella infections in the wife and son of a laboratory worker were documented; the first case was fatal. Neither patient had had any contact with the laboratory. The infecting organisms were Salmonella typhi and a multiply resistant strain of Salmonella agona tha...

CONTEXT Ceftriaxone, an expanded-spectrum cephalosporin, is an antimicrobial agent commonly used to treat severe Salmonella infections, especially in children. Ceftriaxone-resistant Salmonella infections have recently been reported in the United States, but the extent of the problem is unknown. OBJECTIVES To summarize national surveillance data for ceftriaxone-resistant Salmonella infections ...

INTRODUCTION This publication presents data on Salmonella reports from livestock species in Great Britain (England, Wales and Scotland) collected and collated by the Animal and Plant Health Agency (APHA) during 2014 and also provides data from previous years for comparative purposes. The data in the first eleven chapters cover reports of Salmonella in livestock, with separate chapters for the m...

To elucidate the pathogenic mechanism of Salmonella enterica serovar Gallinarum, we examined the expression of the genes encoded primarily in Salmonella pathogenicity island 1 (SPI-1) and SPI-2. These genes were found to be induced as cultures entered stationary phase under high- and low-oxygen growth conditions, as also observed for Salmonella serovar Typhimurium. In contrast, Salmonella serov...

Chronic infections caused by persistent pathogens represent an important health problem. Here, we establish a simple practical mouse Salmonella infection model for identifying bacterial maintenance functions that are essential for persistency. In this model, a substantial fraction of Salmonella survived even several days of treatment with a potent fluoroquinolone antibiotic indicating stringenc...