many years ago the treatment of sarcoma was radiotherapy up to 2000-4000 rad. this treatment was very complicated, due to producing neoplasm after radiotherapy. by this method of treatment of osteosarcoma, the rate of survival became about 20% (two years). the second method of treatment was chemotherapy for a period of 2-5 weeks that amputation was performed afterwards. by chemotherapy, the rat...

Despite the importance of the Newsvendor model, little attention has been paid to its robustness with respect to the estimation of one of its inputs, the salvage value. This oversight is inappropriate because we show that the performance of the Newsvendor model is quite sensitive to the particular method chosen to estimate the salvage value. We highlight two reasons for this sensitivity: small ...

BACKGROUND We previously reported 48-month patency rates of composite sequential bypass (CSB) approaching 60%. Yet, extended patency and limb salvage rates are unknown. HYPOTHESIS Long-term patency and limb salvage rates of CSB are affected by sex, bypass configuration, and warfarin therapy. DESIGN Medical records of all patients who underwent CSB during a 10-year period were retrospectivel...

We summarize the documented and potential impacts of salvage logging--a form of logging that removes trees and other biological material from sites after natural disturbance. Such operations may reduce or eliminate biological legacies, modify rare postdisturbance habitats, influence populations, alter community composition, impair natural vegetation recovery, facilitate the colonization of inva...

To thrive in diverse environments, bacteria must shift their metabolic output in response to nutrient bioavailability. In many bacterial species, such changes in metabolic flux depend upon lipoic acid, a cofactor required for the activity of enzyme complexes involved in glycolysis, the citric acid cycle, glycine catabolism, and branched chain fatty acid biosynthesis. The requirement of lipoic a...

PURPOSE We evaluated our experience with low-dose-rate salvage brachytherapy for local recurrence after primary prostate radiotherapy, and described the changes in lower urinary tract symptoms and health-related quality of life. MATERIAL AND METHODS Between 2011 and 2016, eight men with local recurrence after primary prostate radiotherapy underwent iodine-125 salvage brachytherapy with a pres...

PURPOSE Androgen deprivation therapy is often used as salvage treatment in men with rising prostate specific antigen after initial radical prostatectomy or radiotherapy for clinically localized prostate cancer. Given the lack of evidence from general practice, we examined the association of salvage androgen deprivation therapy with mortality in an observational cohort study. MATERIALS AND MET...

Most glioblastoma (GBM) cases recur within a year and almost all cases recur at some point. Standard treatment for recurrent GBM has not yet been established. We investigated the outcome of various salvage treatments for recurrent GBM. Retrospective analysis was undertaken in 144 patients who received salvage treatment at the time of first progression after maximum debulking surgery followed by...