BACKGROUND During its developmental cycle within the sand fly vector, Leishmania must survive an early proteolytic attack, escape the peritrophic matrix, and then adhere to the midgut epithelia in order to prevent excretion with remnants of the blood meal. These three steps are critical for the establishment of an infection within the vector and are linked to interactions controlling species-sp...

Sand fly salivary proteins are on the spotlight to become vaccine candidates against leishmaniasis and to markers of exposure to sand fly bites due to the host immune responses they elicit. Working with the whole salivary homogenate entails serious drawbacks such as the need for maintaining sand fly colonies and the laborious task of glands dissection. In order to overcome these difficulties, p...

The stage-regulated HASPB and SHERP proteins of Leishmania major are predominantly expressed in cultured metacyclic parasites that are competent for macrophage uptake and survival. The role of these proteins in parasite development in the sand fly vector has not been explored, however. Here, we confirm that expression of HASPB is detected only in vector metacyclic stages, correlating with the e...

Subseasonal forecast skill over the broadly defined North American (NAM), West African (WAM) and Asian (AM) summer monsoon regions is investigated using three Ensemble Prediction Systems (EPS) at sub-monthly lead times. Extended Logistic Regression (ELR) is used to produce probabilistic forecasts of weekly and week 3–4 averages of precipitation with starts in May–Aug, over the 1999–2010 period....

Rodent baits containing systemic insecticides are potential tools to interrupt the cycle of transmission of Leishmania parasites by killing sand flies that take bloodmeals from rodents as adults. Bio-indicators that can be used in conjunction with rodent-targeted sand fly control methods also have been developed to demonstrate that the insecticide treatments are reaching the targeted life stage...

BACKGROUND Bangladesh, India and Nepal are working towards the elimination of visceral leishmaniasis (VL) by 2015. In 2005 the World Health Organization/Training in Tropical Diseases launched an implementation research programme to support integrated vector management for the elimination of VL from Bangladesh, India and Nepal. The programme is conducted in different phases, from proof-of-concep...

Blow fly larvae found in human corpses at death scenes are important in forensic investigations. These larvae are not only useful as an entomological means to estimate the time elapsed between death and the discovery of the corpse (i.e., postmortem interval or PMI), but they can also be used to detect drugs and other toxic substances which might prove to be the cause of In this regard, the accu...

Differentiation of extracellular Leishmania promastigotes within their sand fly vector, termed metacyclogenesis, is considered to be essential for parasites to regain mammalian host infectivity. Metacyclogenesis is accompanied by changes in the local parasite environment, including secretion of complex glycoconjugates within the promastigote secretory gel and colonization and degradation of the...

We assessed the efficacy of cultivation as a potential management strategy for codling moth, Cydia pomonella L. (Lepidoptera: Tortricidae), and plum curculio, Conotrachelus nenuphar Herbst (Coleoptera: Curculionidae) in apple orchards. Cocooned codling moth pupae and thinning apples infested with plum curculio larvae were cultivated over in the field. Emergence, percent burial, damage to buried...

myiasis is the invasion of vertebrates' tissue by the larvae of a fly of the order diptera. the objective of this paper is to present a rare case of secondary myiasis of ocular infestation by chrysomya bezziana. a 55-year-old female from sar village of mazandaran province, northern iran), referred to khatam al-anbia hospital of mashhad with extensive destruction of left orbital cavity. existenc...