background: malignant melanoma is a highly aggressive malignant melanocytic neoplasm which resists against the most conventional therapies. sea cucumber as one of marine organisms contains bioactive compounds such as polysaccharide, terpenoid and other metabolites which have anti-cancer, anti-tumor, anti-inflammatory and antioxidant properties. the present study was designed to investigate the ...

distributed in Shanxi and Shandong province in China. The roots of this plant have been used as an alternative remedy to the most common traditional Chinese medicine Yin-Chai-Hu (roots of Stellria dichotoma var. Lanceolata Bge) and utilized to treat heat due to yin deficiency, hectic and tidal fever, and infantile malnutrition syndrome in China. Previous chemical investigation on the roots of t...

Ilex asprella, which contains abundant α-amyrin type triterpenoid saponins, is an anti-influenza herbal drug widely used in south China. In this work, we first analysed the transcriptome of the I. asprella root using RNA-Seq, which provided a dataset for functional gene mining. mRNA was isolated from the total RNA of the I. asprella root and reverse-transcribed into cDNA. Then, the cDNA library...

The genus Barbarea has emerged as a model for evolution and ecology of plant defense compounds, due to its unusual glucosinolate profile and production of saponins, unique to the Brassicaceae. One species, B. vulgaris, includes two 'types', G-type and P-type that differ in trichome density, and their glucosinolate and saponin profiles. A key difference is the stereochemistry of hydroxylation of...

Steroidal saponins are natural glycosidic compounds of amphiphilic character. Their diverse biological activities are directly related to the variability of their structural constitutive frameworks, aglycones, and sugars. Several studies have demonstrated the therapeutic potential of steroidal saponins by their capacity to induce program‐ med cell death in different tumor cell lines. The proces...

BACKGROUND Zanthoxylum armatum DC has been an important traditional plant known for its medicinal properties. It is well known for its antimicrobial, larvicidal and cytotoxic activities. METHODS The potential anticancer effects of the methanol extract and the crude saponins from fruit, bark and leaves of Z. armatum on breast (MDA-MB-468 and MCF-7) and colorectal (Caco-2) cancer cell lines usi...

Five new triterpenoid saponins, pastuchoside A (1), B (3), C (5), D (7) and E (9), were isolated from the leaves of Hedera pastuchowii. They have oleanolic acid or hederagenin as aglycone. The structures were established by NMR spectroscopy including gs (gradient selected)-COSY, gs-HSQC, gs-HSQC-TOCSY and gs-HMBC experiments, and mass spectrometry (ESI-HR-MS). Heptaoside saponins, compounds 1 a...

Approved: -----btl._,~&>"'\_::-.:?"'_""""""'bfT-'.... ,____,,_""""'-._ _..r--===-~"""'"""-C'---------7 lli. Peter R. Cheeke Rebecca J. Hix for the degree ofMasters of Science in Animal Science and Toxicology. Presented on October 29, 1999. Title: Effects of Saponin-containing Extracts on Fat Digestibility. Growth. and Nutrient Availability in Domestic Fowl. Numerous properties of Yucca schidige...