Similar to the enthusiasm for treatment of various ailments that greeted Nicotiana tabacum when brought to Europe from the New World 500 years ago, Cannabis sativa is now hailed as a possible treatment for a multiplicity of symptoms1. Embraced by physicians and the people, from commoners to the aristocracy, the enthusiasm for Nicotiana tabacum was questioned by a discerning few with concerns ab...

Cannabis sativa is a plant that has been used for millennia in the treatment of conditions such as chronic pain, rheumatism and epilepsy. Biochemical molecular studies have isolated its components, which are known cannabinoids, mapped complex system endogenous molecules receptors, endocannabinoid system. Studies report importance this physiopathology different organic disorders, fibromyalgia, P...

The Cannabis sativa plant has been exploited for medicinal, agricultural and spiritual purposes in diverse cultures over thousands of years. Cannabis has been used recreationally for its psychotropic properties, while effects such as stimulation of appetite, analgesia and anti-emesis have lead to the medicinal application of cannabis. Indeed, reports of medicinal efficacy of cannabis can been t...

In this paper, the quantitative structure-activity relationship predictive models (QSAR) are presented: prediction model for some of main components cannabis sativa, acute toxicity LD50 (n=45, r2=0.917, q2=0.902), chronic LOAEL (n=35, r2=0.911, q2=0.868), NOAEL(n=22, r2=0.964, q2=0.937), LOEL (n=26, q2=0.863) and NOEL (n=25, r2=0.867, q2=0.802), in addition to carcinogenicity mutagenicity effec...

A doença de Alzheimer vem se tornando cada vez mais comum entre os idosos, uma neurológica degenerativa, progressiva e irreversível. O tratamento é realizado por meio medicamentos com o objetivo minimizar distúrbios da e, dentre tratamentos farmacológicos existentes, destacam-se aqueles base na Cannabis sativa. estudo, teve como Analisar literatura científica uso terapêutico sativa no Alzheimer...

Cannabis sativa L. (Cannabaceae) has a long history of utilization as a fiber and seed crop in China, and its achenes ("seeds") as well as other plant parts have been recorded in Chinese medical texts for nearly 2000 years. While the primary applications of cannabis in Chinese medicine center around the use of the achenes, ancient indications for the female inflorescence, and other plant parts ...

Materials and methods 40 male wistar rats (3-4 month, 320-260 g) were completely divided into 4 experimental groups and control group. Cannabis sativa seed was extracted with Soxhlet apparatus. To test spatial memory, Morris water mazemaze (7 days,4 trails) was used. Experimental groups with 50 mg.kg, 100 mg.kg, 150 mg.kg, 210 mg.kg were injected in the peritoneal (IP) orderly and after one hou...

Twenty-one plants were identified through pre were selected for in vitro anti-helminthic activity against that were initially screened, five gave appreciable posit ED50s obtained were: 1.62mg/ml (Tetradenia riparia), 12.50 mg/ml (Carica papaya) and 16.75mg/ml (Mo findings showed that Tetradenia riparia, Cassia occiden foetida and Erythrina abysinnica may be of value in whereas Moringa oleifera ...

Cannabinoid receptors are the targets of the psychoactive component of the plant Cannabis sativa (marijuana), delta-9-tetrahydrocannabinol (THC). Type-1 cannabinoid receptors (CB1) are the G protein coupled receptors most abundantly expressed in the brain and mediate most of the effects of THC. Our recent work demonstrated that CB1 receptors are expressed in many different brain cells where the...