The yeast HO gene is tightly regulated, with multiple activators and coactivators needed to overcome repressive chromatin structures that form over this promoter. Coactivator binding is strongly interdependent, as loss of one factor sharply reduces recruitment of other factors. The Rpd3(L) histone deacetylase is recruited to HO at two distinct times during the cell cycle, first by Ash1 to the U...

This paper reports on the response of hydroxyapatite (HA) coatings, fabricated using two deposition technologies, to immersion in simulated body fluid (SBF). The deposition methods used were: plasma spray, a commercial standard, and CoBlast, a novel low temperature microblast technique. In the case of the latter, HA coatings are deposited by simultaneous blasting HA and abrasive powders concent...

Expression of the chicken U4B small nuclear RNA (snRNA) gene is stimulated by a transcriptional enhancer located approximately 190-227 base pairs upstream of the transcription start site. This enhancer is composed of at least two functional motifs: an octamer (binding site for Oct-1) and an SPH motif. We now report that these two motifs functionally cooperate to stimulate U4B snRNA gene express...

The impregnation of sodium hypochlorite (NaOCl) treated corals (Favia Stelligera) from Red Sea coast, Egypt with two moles of either divalent (Sr 2+ , Zn 2+ ) or mono valent (Ag + ) ions for 6 hours at ambient conditions was performed. Subsequent effect on hydroxyapatite (HA) deposition upon immersion in saline and simulated body fluid (SBF) solutions up to 72 h was followed through measuring r...

Introduction: In humans skin blood flow (SBF) plays a major role in body heat loss. Therefore the accuracy of models of human thermoregulation depends for a great deal on their ability to predict skin blood flow. Most SBF-models use body temperatures directly for calculation of skin perfusion. However, humans do not sense temperature directly, yet the information is coded into neuron fire rates...

Footrot is a costly endemic disease of sheep. This study investigates the potential to decrease its prevalence through selective breeding for decreased lesion score. Pedigreed mule and Scottish Blackface (SBF) ewes were scored for lesions on each hoof on a 0 to 4 scale for up to 2 (SBF ewes) or 4 (mules) times over 2 ye...

BACKGROUND AND PURPOSE Ultrasound imaging is a very essential technique in medical diagnosis due to its being safe, economical and non-invasive nature. Despite its popularity, the US images, however, are corrupted with speckle noise, which reduces US images qualities, hampering image interpretation and processing stage. Hence, there are many efforts made by researches to formulate various despe...

Creative design often involves large, complex modifications to the design topology. Making these modifications typically requires transfer of design configurations from different designs to the new problem. We describe an analogical theory of creative design called modelbased analogy (MBA). In this theory, case-specific structure-behaviorfunction (SBF) models of past designs enable abstraction ...

BACKGROUND Vascular dysfunction due to hyperglycemia in individuals with diabetes is a factor contributing to distal symmetric polyneuropathy (DSPN). Reactive oxygen species reduce the bioavailability of nitric oxide (NO), a powerful vasodilator, resulting in reduced circulation and nerve ischemia. Increases in blood NO concentrations and circulation have been attributed to whole body vibration...

Time perception in the second-to-minutes range is crucial for fundamental cognitive processes like decision making, rate calculation, and planning. We used a striatal beat frequency (SBF) computational model to predict the response of an interval timing network to intruders, such as gaps in conditioning stimulus (CS), or distracters presented during the uninterrupted CS. We found that, dependin...