PURPOSE This study tested the hypothesis that intraocular pressure (IOP) elevations, induced by controlled increase of intraocular volume, are correlated with the biomechanical responses of the posterior sclera. METHODS Porcine globes were tested within 48 hours postmortem. The first group of globes (n = 11) was infused with 15 μL of phosphate-buffered saline at three different rates to inves...

Background: Recurrent pterygium poses distinct problem like high postoperative recurrences and many surgical approaches have been tried to decrease recurrences. Currently, mitomycin C (MMC) application and amniotic graft are used as adjunct apart from the standard limbal-conjunctival autograft. Aim of study: Aim of this study is to determine through meta-analysis, the risk of recurrences and fr...

The role of cell proliferation in the formation of scleral ectomesenchymal condensations underlying the conjunctival papillae was examined with in vivo tritiated thymidine labelling in chick embryos ranging in age from 8 days 0 h to 10 days 12 h. Percentages of labelled nuclei were determined in both ectomesenchyme and the deeper fibrous sclera for short-term and continuous tritiated thymidine ...

Developing more effective ocular drug delivery systems is essential to improving the treatment of posterior segment eye disease. The large target area provided by the sclera and potentially less vision threatening complications are advantages of transscleral administration compared to more traditional modalities of drug delivery to the posterior segment. We aimed to determine the permeability c...

The distribution of proteoglycans and their association with collagen fibrils were studied in human and rabbit sclera following fixation of tissue in glutaraldehyde containing Cuprolinic Blue, a specific stain for proteoglycans when used in the presence of critical concentrations of electrolytes. Proteoglycans were visualized by electron microscopy as fine filaments, approximately 54 nm in leng...

Statement of Purpose: The design of a bioreactor for study of the ocular sclera is described. The sclera, which is the outer connective tissue layer of the eye, is altered in myopia (near-sightedness), exhibiting thinning due to decreased collagen synthesis and increased levels of active matrix metalloproteinase 2 (MMP-2). We have previously reported the development of enzymaticallydegradable s...

We report a case of choroidal melanoma with massive extraocular extensions through the sclera. A 64-year-old woman reported blurred vision in her right eye. At the first visit, visual acuity was 10/20 OD. An ophthalmological examination revealed a raised choroidal mass and exudative retinal detachment in the lower retina. A diagnosis of peripheral choroidal melanoma was confirmed by additional ...

We present the case of successful repair of an exposed glaucoma drainage tube by cornea graft fixation with tissue adhesive, and without subsequent coverage by adjacent conjunctiva or donor tissues. Patient with history of keratoglobus with thin cornea and sclera, and phthisical contralateral eye, underwent three unsuccessful corneal grafts followed by Boston type 1 keratoprosthesis in the righ...

IntRoductIon Osteogenesis imperfecta (OI), also known as brittle bone disease or Lobstein syndrome, is characterized by blue or gray sclerae, variable short stature, dentinogenesis imperfecta, hearing loss, and recurrent fractures. Based on clinical, genetic, and radiological features, Sillence et al.[1] classified the OI into four subtypes including type I: Mild, common, with blue sclera; type...