Virosecurinine, a primary alkaloid from Securinega suffruticosa plant is known as a potent differentiation-inducing agent in acute leukemia cells. The present study aimed to investigate the effects and underlying mechanisms of virosecurinine on human leukemia THP-1 cells in vitro. The effects of virosecurinine on cell proliferation were assessed by CCK-8. The effects on apoptosis and cell cycle...

The Securinega alkaloids are a class of natural products isolated from plants of the Euphorbiaceae family. L-securinine induces apoptosis in the human promyelocytic leukemia cell line HL-60 indicating its potential as an efficient natural antitumor drug with low toxicity. The aim of the present study was to investigate the apoptotic effects of L-securinine on HL-60 cells and to explore its pote...

Yoshihiko Ogawa, M.D., Masatoshi Sato, M.D., Takaya Yamashita, Ryuichi Nakano, Ph.D, Satoshi Mochizuki, M.D., Kei Kasahara, M.D., Hisakazu Yano, M.D., and Keiichi Mikasa, M.D. Center for Infectious Diseases and Department of Microbiology and Infectious Diseases, Nara Medical University, Nara, Japan; Department of Infectious Diseases, Department of Clinical Laboratory and Department of Surgery, ...