chiral pyrrolidines and pyrrolizidines with spirooxindole ring systems are the central skeletons for numerous alkaloids and pharmacologically important compounds. gelesmine, pseudotabersonine, formosanine, isoformosanine, morroniside and mitraphylline are some of the alkaloids containing spirooxindole ring systems. derivatives of spirooxindole find very wide biological applications as anti micr...

A method for the synthesis of 1,3-diarylpropylamines through hydroalkylation styrenes with benzylamines by potassium hydride has been developed. The protocol is initiated solvothermal treatment KH at 100 °C to generate deprotonated anionic species, which undergo selective C-alkylation arylalkenes 0 ambient temperature afford as major product.

Selective cyclization of cationic alkynes is a useful tool for the synthesis biomolecules such as steroids. In their Research Article (DOI: 10.1002/chem.202204028), A. de Cózar, Arrieta and F. P. Cossío analyze computationally how nature alkyne determines size ring why conformation fused rings dictates stereoselectivity process.

A short total synthesis of tunicamycin V (1), a non-selective phosphotransferase inhibitor, is achieved via Büchner–Curtius–Schlotterbeck type reaction. Tunicamycin can be synthesized in 15 chemical steps from D-galactal with 21 % overall yield. The established synthetic scheme operationally very simple and flexible to introduce building blocks interest. inhibitory activity one the designed ana...