In Alzheimer’s disease (AD) brains, reactive astrocytes and microglia are frequently seen around amyloid plaques. The functions of have been extensively studied, such as the neuroprotective barrier they form to prevent plaque growth their release inflammatory cytokines. However, less well known. Here I review ongoing research on astrocytic Recent studies suggest that play an important role in d...

BACKGROUND The monoamine oxidase (MAO) inhibitor selegiline has demonstrated antidepressant efficacy superior to placebo. A selegiline transdermal system (STS) has been developed with unique pharmacokinetic and pharmacodynamic properties that allow inhibition of central nervous system MAO-A and MAO-B enzymes while substantially avoiding inhibition of intestinal and liver MAO-A enzyme. This nove...