In this paper,wepropose a newparallel optimization algorithm that combines ideas from the fields of metaheuristics and Systolic Computing. The algorithm, called Systolic Genetic Search (SGS), is designed to explicitly exploit the high degree of parallelism available in modern Graphics Processing Unit (GPU) architectures. In SGS, solutions circulate synchronously through a grid of processing cel...

We introduce a new sequential algorithm for making robust predictions in the presence of changepoints. Unlike many previous approaches [1], which focus on the problem of detecting and locating changepoints, our algorithm focuses on the problem of making predictions even when such changes might be present. We introduce nonstationary covariance functions to be used in Gaussian process prediction ...

Stress granules (SGs) are cytoplasmic bodies wherein translationally silenced mRNAs are recruited for triage in response to environmental stress. We report that Drosophila cells form SGs in response to arsenite and heat shock. Drosophila SGs, like mammalian SGs, are distinct from but adjacent to processing bodies (PBs, sites of mRNA silencing and decay), require polysome disassembly, and are in...

Stress granules (SGs) are cytoplasmic RNA multimeric bodies that form under stress conditions known to inhibit translation initiation. In most reported stress cases, the formation of SGs was associated with the cell recovery from stress and survival. In cells derived from cancer, SGs formation was shown to promote resistance to either proteasome inhibitors or 5-Fluorouracil used as chemotherape...

Pattern reordering is proposed as an alternative to sequential and batch processing for online category learning. Upon detecting that the categorization of a new input pattern is ambiguous, the input is postponed for a predefined time, after which it is reexamined and categorized for good. This approach is shown to improve the categorization performance over purely sequential processing, while ...

This paper introduces a new approach to Large-Eddy Simulation (LES) where subgrid-scale (SGS) dissipation is applied proportionally to the degree of local spectral broadening, hence mitigated or deactivated in regions dominated by large-scale and/or laminar vortical motion. The proposed coherentvorticity preserving (CvP) LES methodology is based on the evaluation of the ratio of the test-filter...

The sequential testing of more than two hypotheses has important applications in direct-sequence spread spectrum signal acquisition, multiple-resolution-element radar, and other areas. A useful sequential test which we term the MSPRT is studied in this paper. The test is shown to be a generalization of the Sequential Probability Ratio Test. Under Bayesian assumptions, it is argued that the MSPR...

Cells form stress granules (SGs) in response to environmental stresses, which constitute cytoplasmic domains where mRNAs are stored and translation is halted. Although several components are found in SGs, it is poorly understood as to how SGs are formed and dissolved. We identified growth factor receptor-bound protein 7 (Grb7), an RNA-binding, translational regulator, as an integral component o...

Today’s fabrication technologies are allowing increasing functionality on a single chip. Consequently, for complex consumer products like the SGS-Thomson single chip videophone [1], new design and verification methods are needed to address the interfunctioning on-chip hardware and software components. Complementing standard hardware practices, this article presents contributing techniques in ha...