Background: Diagnosis of osteonecrosis of the femoral head (ONFH) is complicated due to the lack of reliable serum biomarkers. Up-regulation of alpha-2-macroglobulin (A2M) gene has been reported in glucocorticoid-induced ANFH rat model. This study aimed to investigate whether the serum level of alpha-2-macroglobulin (A2M) can be used for ONFH diagnosis. Methods: Serum protein capillary elect...

thyrotoxicosis is a condition in which tissues are stimulated by increased secretion of thyroid hormone. the most common cause is diffuse toxic goiter and toxic multi-nodular goiter. for more reviews on this disease, the effects of hyperthyroidism on liver enzyme levels were studied. a total of 30 adult male wistar rats weighing about 190 g were purchased from the pasteur institute of iran. in ...

Cholinesterase (ChE) is a group of enzymes that hydrolyze cholinester. There are two ChE isoenzymes in the blood, namely Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE). Both required process sending nerve signals. The activity these will be decreased by exposure to toxic chemical agents, insecticides such as organophosphates or carbamates, anesthetic drug therapy for Alzheimer’s d...

Abstract Introduction/objective Ovarian cancer is the 6th leading cause of mortality in women, killing more women than any other reproductive system cancer. We studied expression serum micro-ribonucleic acid-21 ( miRNA-21 ) ovarian patients and explored associations with diagnosis, clinicopathological parameters, prognosis. Methods Real-time fluorescence-quantitative polymerase chain reaction w...

p-Hexosaminidase (EC 3.2.1.30) is markedly increased in human serum in liver disease, chronic alcoholism, and pregnancy. Knowledge of the clearance rate of plasma! serum #{237}3-hexosaminidase is n cessary to evaluate this increase. We studied the plasma clearance of p3-hexosaminidase isoenzymes (purified from human serum and placenta) after their infusion into rat circulation. A recently devel...

The influence of the amount of heparin injected on the contributions of liver and of extrahepatic tissues to the lipase activity of postheparin serum of the rat was studied. It was found that when high doses of heparin (20 I.U./lOO g bodyweight) were injected, the liver contributes for 63% to the total triacylglycerol lipase activity of postheparin serum. At low heparin levels (0.4 I.U./lOO g b...

the effects of therapeutic doses of dillsun, garsin, antum and statins on rat liver cytosolic phosphatidate phosphohydrolase (pap) activity, a key enzyme in triacylglycerol synthesis, and on serum and liver lipids were examined. lovastatin and simvastatin both stimulated the enzyme activity by 29% and 43%, respectively. the stimulatory effects were dose-dependent and accompanied by the decline ...

the aim of the present study was to determine the protective action of silymarin on acute toxicity due totetracycline severe overdose in cats. thirty healthy cats were randomly allotted into five equal groups. catsin group a were given tetracycline (single dose 120 mg⁄kg, p.o.); group b consisted of cats that receivedsilymarin (single dose 30 mg⁄kg, p.o.) concurrent with tetracycline administra...

FOLLOWING tissue damage several tissue enzymes are released into the serum. On this basis, changes in serum glutamate-oxalacetate transaminase and lactate dehydrogenase have been used as indicators of the occurrence and severity of myocardial infarction. These tests lack specificity because damage to liver and other organs also causes an increase in the serum levels of these enzymes. Recently w...