Chorionic gonadotropin (CG) is an essential signal in establishment and maintenance of pregnancy in humans and higher primates. A G-to-A transition in exon 3 of human CGbeta gene 5, changing the naturally occurring valine residue to methionine in codon 79 (Val(79)Met) has been reported at carrier frequency 4.2% in a random population from the Midwest of the United States. The biological activit...

Measurement of serum human chorionic gonadotropin (HCG) concentration is a standard method to detect pregnancies after in vitro fertilization (IVF). Radio immune assay or for HCG targeting the specific beta subunit of HCG dimer was established more than 30 years ago [1,2]. Today, more advanced assay methods are widely used in many medical institutes. While transvaginal ultrasound can detect pre...

background and objective: hyperemesis gravidarum (hg) is defined as vomiting sufficiently severe to produce weight loss, dehydration, electrolyte abnormalities. interleukin-6 (il-6), a pro-inflammatory and trophoblast-derived cytokine has ability to induce trophoblasts to secrete human chorionic gonadotropin (hcg). the purpose of our study was to assay the level of il-6 and β-hcg in serum of pr...

BACKGROUND Increased serum progesterone on the day of human chorionic gonadotropin administration may affect in vitro fertilization (IVF) outcome. OBJECTIVE The aim of this study was to evaluate whether progesterone elevation on the day of human chorionic gonadotropin administration is associated with poor IVF outcome. MATERIALS AND METHODS To determine the relationship between serum proges...

Choriocarcinoma is the most aggressive, malignant form of gestational trophoblastic disease and has varying incidence, increasing in patients older than 40 years. It usually develops after a malignant alteration in a molar pregnancy, but rarely after an abortion or normal or ectopic pregnancies. The most common localization is the uterus, but it can also be found rarely in the ovaries, fallopia...

BACKGROUND The effect of progesterone elevation (PE) on the day of human chorionic gonadotropin (hCG) administration on the pregnancy outcomes of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles is a matter of ongoing debate. The replacement of cleavage-stage embryos with blastocyst-stage embryos for transfer was proposed to avoid the possible impairment of PE in fresh ...