To assess the correlation between the remaining serum testosterone and bone mineral density(BMD), and to determine the effect of exogenous testosterone on BMD in subjects with male hypogonadism, we evaluated the serum testosterone levels and BMDs of the femur neck, Ward's triangle and the spine(L1-4) in 20 subjects with Klinefelter's syndrome and 7 with hypogonadotropic hypogonadism before and ...

Serum testosterone is a potential marker to distinguish between indolent and aggressive prostate cancer (PCa). The present study aimed to investigate whether low levels of total serum testosterone at diagnosis were associated with aggressive PCa and poor clinical outcomes. In total, 762 non-Hispanic Caucasian men with previously untreated PCa were recruited from The University of Texas MD Ander...

PURPOSE This study was conducted to investigate the relationship between serum total testosterone levels and scores on the Aging Male's Symptom (AMS) scale and the International Index of Erectile Function (IIEF) in men with erectile dysfunction with testosterone deficiency syndrome (TDS). MATERIALS AND METHODS From January 2005 to July 2008, 134 patients who complained of sexual dysfunction s...

In this method, we use the Amicon MPS-1 centrifugal ultrafiltration device and the YMB membrane in measuring free testosterone in serum. Two independent assays are combined: total testosterone and the ultrafiltrable fraction of added [3H]testosterone. The unbound fraction is determined in 0.15-0.5 mL ultrafiltrates of 0.6 to 1 mL of variably diluted serum that has been equilibrated with [3H]tes...

Androgen deprivation therapy is frequently used to treat patients with advanced prostate cancer. New therapies for metastatic castration-resistant prostate cancer have drawn increased attention to serum and intratumoral testosterone levels. The present review examines the role of testosterone in prostate cancer progression, discusses the nuances and potential pitfalls in measuring serum testost...

Abstract. In Chronic Kidney disease (CKD) there are various abnormalities in hormonal levels that lead to impairment of sexual functions, fertility, and pregnancy outcomes. Sex dysfunction not only affects the aspect human life but has a direct indirect impact on other aspects like bone health, central nervous system, cognitive function. this study, we looked at testosterone gonadotropins their...

introduction: numerous studies have demonstrated that kisspeptin, a peptide from the kiss1 gene, plays an important role in regulating the secretion of gonadotropin releasing hormone (gnrh). also, there is some evidence suggesting that kisspeptin can interact with other neuropeptides for the control of the reproductive axis. in the present study, we have investigated the effect of central admin...

All delivery forms of testosterone should be equally efficacious in treating the androgen-deficient aging male if adequate serum testosterone levels are obtained. The testosterone preparations available in North America include the oral undecanoate, injectable testosterone esters, the scrotal patch, the nonscrotal transdermal patch, and the transdermal gels. Selection of a specific testosterone...

Aim: To compare serum gelsolin levels of women with androgenetic alopecia PCOS and patients non-PCOS alopecia. Materials Methods: A total 30 who applied to our dermatology clinic the complaint hair loss were diagnosed (AGA) included in study. Thirty not but AGA considered as control group. Patients group matched terms age. was cases widespread thinning on scalp preservation frontal hairline. Al...

OBJECTIVE To study the disposition of serum testosterone and seven of its metabolites before and after 2 days of an intramuscular dose (500 mg) of testosterone enanthate in relation to the phosphodiesterase (PDE7B) and the uridine 5'-diphospho-glucuronosyltransferase (UGT2B17) genotypes. METHODS Patients were genotyped for UGT2B17 deletion polymorphism and single nucleotide polymorphisms in t...