BACKGROUND Androgens are thought to have an adverse effect on female scalp hair growth. However, our clinical experience of androgen replacement therapy in women with androgen deficiency, in which hair loss was seldom reported, led us to question this concept. OBJECTIVES To evaluate the effect of subcutaneous testosterone therapy on scalp hair growth in female patients. METHODS A total of 2...

PURPOSE A history of prostate cancer has been a longstanding contraindication to the use of testosterone therapy due to the belief that higher serum testosterone causes more rapid prostate cancer growth. Recent evidence has called this paradigm into question. In this study we investigate the effect of testosterone therapy in men with untreated prostate cancer. MATERIALS AND METHODS We report ...

PURPOSE We evaluated the variation in serum testosterone in normal aging men and its relationship with erectile function. MATERIALS AND METHODS In a study that was not community based and during a free screening program for prostate cancer 1,071 men were invited to complete a sexual activity questionnaire, that is the abridged 5-item version of the International Index of Erectile Function (II...

Men with low testosterone concentrations are usually hypogonadal. However, because variations in the testosterone transport protein, sex hormone-binding globulin (SHBG), directly influence the total testosterone concentration, confirmation of a low testosterone with a measurement of free testosterone or "bioavailable" testosterone (BAT) is recommended. In the present study, we examined the rela...

background: danae racemosa is a strong antioxidant and antioxidants have significant effects on spermatogenesis, sperm biology and oxidative stress, and changes in antioxidant capacity are considered to be involved in the pathogenesis of chronic diabetes mellitus. objective: because stz causes testicular dysfunction and degeneration under situations of experimentally induced diabetes in animal ...

BACKGROUND A significant and independent association between testosterone levels and coronary events in men and women has not been confirmed in large prospective studies, although some reports have shown that endogenous testosterone concentrations in men are inversely related to cardiovascular and general mortality. METHODS We aimed to assess the relationship between serum testosterone level ...

Abstract Introduction Testosterone therapy is available in multiple delivery systems such as gels and injections; however, oral formulations have been unavailable the United States due to hepatotoxicity variable bioavailability. Oral of testosterone are convenient, easy use, avoid problems other forms therapy. Jatenzo (testosterone undecanoate) a novel US FDA-approved capsule that provides unif...

BACKGROUND Exposure to perfluorooctane sulfonic acid (PFOS) or to perfluorooctanoic acid (PFOA) increases mouse and human peroxisome proliferator-activated receptor alpha (PPARα) subtype activity, which influences lipid metabolism. Because cholesterol is the substrate from which testosterone is synthesized, exposure to these substances has the potential to alter testosterone concentrations. O...

BACKGROUND It has been hypothesized that high androgen levels are determinants of prostate carcinoma. METHODS Serum concentrations of testosterone, sex hormone-binding globulin (SHBG), and androstenedione were analyzed to determine their role as predictors of prostate carcinoma in a longitudinal, population-based, nested case-control study. The serum concentrations of testosterone, SHBG, and ...

OBJECTIVE To investigate the effects of moderate-intensity and low frequency exercise on resting serum testosterone and cortisol levels, resting heart rate, and isokinetic strength among healthy sedentary young men. DESIGN A randomized controlled study. Forty sedentary young men aged 18 to 25 years old, pedaled 50 minutes on a bicycle ergometry at 60% of maximal effort once a week for 12 week...