نتایج جستجو برای: sex and genotype
تعداد نتایج: 16854175 فیلتر نتایج به سال:
BACKGROUND Prior studies have examined independent effects of a dopamine receptor D4 polymorphism (DRD4-7) and lead exposure on executive functions but not their interaction or the role of sex as a modifier of their effects. METHODS Multivariable analyses were used to examine effects of DRD4-7 genotype, 60-month blood lead level, and sex on spatial working memory, rule learning and reversal, ...
The aim of the present study was to evaluate effect two dietary protein levels on performance, carcass characteristics, and meat quality parameters in fast- (Ross 308), medium- (JA757), slow-growing (ISA Dual) chickens assess interaction factors. Each genotype divided into a control group fed commercial type feed mixture an experimental low-protein diet (LP). trial terminated after common perio...
Asthma is a complex disease with sex-specific differences in prevalence. Candidate gene studies have suggested that genotype-by-sex interaction effects on asthma risk exist, but this has not yet been explored at a genome-wide level. We aimed to identify sex-specific asthma risk alleles by performing a genome-wide scan for genotype-by-sex interactions in the ethnically diverse participants in th...
Individual response to drugs is highly variable and largely influenced by genetic variants gene-expression profiles. In addition, it has been shown that strongly sex-dependent, both in terms of efficacy toxicity. To expand current knowledge on sex differences the expression genes relevant for drug response, we generated a catalogue differentially expressed human transcripts encoded 289 41 tissu...
Conventional genetics assumes common variance among alleles or genetic groups. However, evidence from vertebrate and invertebrate models suggests that residual genotypic variance may itself be under partial genetic control. Such a phenomenon would have great significance: high-variability alleles might confound the detection of "classically" acting genes or scatter predicted evolutionary outcom...
INTRODUCTION CYP19A1 encodes aromatase, the enzyme responsible for the conversion of androgens to estrogens, and may play a role in variation in outcomes among men and women with cardiovascular disease. We sought to examine genetic variation in CYP19A1 for its potential role in sex differences in cardiovascular disease outcomes. METHODS Caucasian individuals from two independent populations w...
BACKGROUND Research has demonstrated an association between exposure to early life stress and an increased risk of psychiatric disorders in later life, in particular depression. However, the mechanism through which early life stress contributes to disease development remains unclear. Previous studies have reported an association between early life stress and altered methylation of the serotonin...
The Hutterite Brethren are a genetic isolate characterized by high indices of relatedness and a communal agrarian lifestyle. We hypothesized that variation in their apolipoprotein (apo) E and lipoprotein lipase (LPL) genes would be associated with variation in fasting plasma lipoproteins. We measured plasma lipids, lipoproteins, and apolipoproteins and analyzed DNA for genotypes of apoE and LPL...
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