It is known that long‑term excessive administration of glucocorticoid (GC) results in osteoporosis. The present study aimed to evaluate the protective effects of Polygonum multiflorm (PM) on the bone tissue of rats with GC‑induced osteoporosis (GIO). A total of 90 6‑month‑old female Sprague Dawley rats (weight range, 190‑210 g) were randomly divided into nine groups: Control (normal saline); pr...

The last 350 years since the publication of the first medical monograph on rickets (old English term wrickken) (Glisson et al., 1651) have seen spectacular advances in our understanding of mineral-homeostasis. Seminal and exciting discoveries have revealed the roles of PTH, vitamin D, and calcitonin in regulating calcium and phosphate, and maintaining healthy teeth and skeleton. However, it is ...

OBJECTIVE This study aimed to evaluate whether circulating levels and/or visceral adipose tissue (VAT) expression of recently described adipokines associate with histopathological severity of nonalcoholic fatty liver disease (NAFLD), independent of obesity and insulin resistance. METHODS Serum levels of adiponectin, omentin, chemerin, monocyte chemoattractant protein-1, and secreted frizzled-...

Implantation in humans is a complex process that is temporally and spatially restricted. Over the past decade, using a one-by-one approach, several genes and gene products that may participate in this process have been identified in secretory phase endometrium. Herein, we have investigated global gene expression during the window of implantation (peak E2 and progesterone levels) in well charact...

On the basis of their differential location within dermis and discrete changes in gene protein expression, two major fibroblast subtypes (papillary reticular) have traditionally been distinguished. In last 3 years, a number research groups begun to address transcriptomic heterogeneity human skin cells at single-cell level by determining mRNA levels expressed genes through RNA sequencing technol...

CD24 is overexpressed in many human cancers and a driver of tumor progression. Herein, molecular mechanisms leading to up-regulation prostate cancer were studied. DNA methylation the gene promoter at four loci using quantitative methylation-specific PCR was evaluated. Expression tissues studied by immunohistochemistry. To corroborate results vitro, ERG-inducible LNCaP TMPRSS2:ERG (T2E) cells lu...