The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is described in a 67-year-old man with cerebellar and cerebral atrophy. This is the first reported case of this association.

Objective. To report the rare case of a thymic neuroblastoma, in an elderly woman with SIADH at presentation. Methods. Clinical and biochemical data of the patient are presented and the pertinent literature is reviewed. Results. a 79-year-old woman was admitted into our department with worsening asthenia, severe hyponatremia (114.8 mEq/L), low plasma osmolarity (253 mEq/L), and inappropriate ur...

The aim of this work was to investigate histopathologically the relationship between the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) and kidney abnormalities and the therapeutic efficacy of VP-343 ((N-[4-[[(2S,3aR)-2-hydroxy-2,3,3a,4-tetrahydropyrrolo[1,2-alqunoxalin-5(1H)-yl]phenyl]-4'-methyl[1,1'-biphenyl]-2-carboxamide], a selective vasopressin V2 receptor antagonist,...

The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is not so frequent but it is a representative entity of hyponatremia. Although the clinical features were established by Bartter and Schwartz more than 30 years ago (1), a prototype of their diagnostic criteria has been applied so far. Hyponatremia is not a rare condition, especially in elderly persons. Nearly 1 to 5% of ho...

Introduction The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a serious condition associated with persistently high ADH water retention despite sufficient vascular volume. Sodium valproate (VPA), an antiepileptic indicated to treat bipolar disorder, blocks sodium (Na) and calcium ions. Few studies have examined the association between VPA SIADH. Objectives This abstract h...

The purpose of this study was to determine the efficacy and safety tolvaptan in Japanese patients with hyponatremia secondary syndrome inappropriate secretion antidiuretic hormone (SIADH). This multicenter, open-label, dose-escalation, phase III enrolled (20–85 years old) SIADH who were unresponsive fluid restriction. Oral administered for up 30 days, initially at 7.5 mg/day, but escalated dail...

Acute intermittent porphyria (AIP) is a rare condition characterized by abdominal pain and a wide range of nonspecific symptoms. We report the case of a 24-year-old woman with syndrome of inappropriate secretion of antidiuretic hormone (SIADH) and motor and sensory neurological deficits due to an attack of acute porphyria. The patient presented to the emergency department with abdominal pain. T...

To the Editor: The review by Sterns (Jan. 1 issue)1 on disorders of plasma sodium concentration, which are among the most frequently encountered (and mismanaged) problems in medicine, was enhanced by the use of illustrative cases (which appear in the Supplementary Appendix, available with the full text of the article at NEJM.org). After the second patient had a subarachnoid hemorrhage, plasma h...