Genes for thalassaemias, sickle cell disorders and Glucose-6- phosphate dehydrogenase (G6PD) deficiency are known to be associated with prevalent malaria infection. The prevalence in the heterozygote state for sickle cell anaemia (SCA), G6PD and alpha thalassaemia is between 25-30% in Nigerians but the prevalence for the beta thalassaemia trait (BTT) is low. Under-diagnosis of BTT may arise fro...

Background. This study sought to identify the pattern of electrocardiographic changes in steady state adult sickle cell anaemia. Methods. A case-control, cross-sectional study was conducted amongst sickle cell patients attending the sickle cell clinic of Lagos State University Teaching Hospital, Ikeja, and HbAA controls. All consenting participants had haemoglobin electrophoresis done and were ...

1. Kiryluk K, Jadoon A, Gupta M, Radhakrishnan J. Sickle cell trait and gross hematuria. Kidney Int. 2007;71:706–10. 2. Phuong-Thu TP, Phuong-Chi TP, Alan HW, Susie QL. Renal abnormalities in sickle cell disease. Kidney Int. 2000;57:1–8. 3. World Health Organisation. Sickle cell anaemia. Agenda item 11.4, in 59th World Health Assembly, 27 May 2006. Geneva, Switzerland: World Health Organisation...

This study describes the radiological and pathological findings in a necropsy series of 70 skulls of Nigerian patients with sickle cell gene, and 70 controls matched for sex and age with no sickle cell gene. 6 (35%) of the 17 patients with sickle anaemia, or 17% of 35 patients with sickle cell gene excluding the trait, all under age 10 years, were shown to have bone trabeculae within the diploe...

Nigeria has the fourth highest prevalence of TB and the highest prevalence anaemia (SCA) in the world. SCA patients have impaired immunity and are vulnerable to TB. Hence, we studied the haematological indices of SCA patients with TB in Nigeria. A total of 23 SCA patients with TB were studied in parallel with equa SCA patients without TB. SCA patients with TB had significantly lower haematocrit...

abstract background prevalence of hereditary blood diseases such as sickle cell anemia, sickle thalassemia and thalassemia major are high in khuzestan province. sickle cell anemia and beta-thalassemia are predominantly common in iranian arabs. pulmonary complications account for a large proportion of morbidity and mortality in patients with and sickle cell disease. periodic lung function assess...

Context Sickle cell anaemia (SCA) is a disorder of haemoglobin polymerisation that results in vaso-occlusion and haemolytic anaemia, culminating in organ injury and early mortality. Elevated fetal haemoglobin has been associated with a less severe phenotype leading to an interest in hydroxycarbamide (also known as hydroxyurea) use. The MSH study1 demonstrated that hydroxycarbamide in adults wit...

I n a recent paper, one of the authors (HUCK 1923) has given an account of a comparatively rare disease, so far described only in negroes and mulattoes, which is known as sickle-cell anaemia. The two genealogical charts which his data contain indicate so clearly that the disease is definitely inherited that they seem well worth an analysis. Only a few salient features of the disease need to be ...

Haemoglobinopathies (mainly thalassaemia and sickle-cell anaemia syndromes) and glucose-6-phosphate dehydrogenase deficiency (G6PD) are globally among the most prevalent single-genomic diseases. About 3% of the world's population are heterozygotic for beta-thalassaemia and about 1-2% for sickle-cell anaemia, and it is estimated that more than 400 million people are affected by G6PD deficiency w...