نتایج جستجو برای: sideroblastic anemia
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Defective arythropoiesis characterizes the sideroblastic anemias. The present studies were undertaken to assess the effects of isoniazid, an inhibitor of heme synthesis, on erythropoietin-induced erythroid maturation in hypertransfused mice. Isoniazid was administered at intervals during a wave of induced erythropoiesis, and the effects were assessed in both the bone marrow and peripheral blood...
Mutation analysis of Chinese sporadic congenital sideroblastic anemia by targeted capture sequencing
I N 1953 Synderman et al.16 demonstrated that vitamin B 1 has a role in human hematopoiesis by producing anemia in an infant fed with a vitamin B6-free synthetic diet. In 1956 Harris et al.15 reported the first patient with pyridoxineresponsive anemia ( PRA ) . Since this report appeared, further similar cases have been published.4’ 9.20’253943 In the present article, two brothers with PRA are ...
which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. A 29-year-old female, with a 3-year history of anemia and iron therapy, admitted for the work-up of refractory anemia. Blood cell counts were: leukocyte counts 3.4×10 9 /L, hemoglobin 7.8 g/dL, and platelet counts 155×10 9 /L. Peripheral blood film showed ma...
Copper deficiency is a rare cause of sideroblastic anemia and neutropenia that often is not suspected clinically. The morphologic findings in bone marrow, while not pathognomonic, are sufficiently characteristic to suggest the diagnosis, leading to further testing to establish the correct diagnosis. Excess zinc ingestion is among the causes of copper deficiency. We present 3 cases of zinc-induc...
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