Clinical studies have demonstrated that sildenafil citrate (Viagra) is an effective and well-tolerated oral treatment for erectile dysfunction. Despite its established safety profile, concern about its cardiovascular safety persists among some physicians and the general public. This concern has stemmed primarily from sporadic reports of adverse events published in the literature and sensational...

Background: The site of drug administration, such as oral or intravenous, frequently categorizes the route administration. Drug delivery through jelly reduces product costs and enhances stability appearance. Oral is used a carrier for different diseases like erectile dysfunction, arthritis, hypertension, sore throats. Medicated easy to administer at any time place without water. Aim: To formula...

background: endometrial development has an important role in blastocyst adhesion and implantation. during ivf cycles, endometrial development is enhanced by progesterone. objective: the aim of this study was to compare ultrastructural and morphometrical characteristics of mice uterine endometrium in natural cycle with those in superovulated cycles received progesterone or sildenafil. materials ...

Background: Erectile dysfunctions in diabetes are important signs probably due to pelvic autonomic neuropathy with damage to the parasympathetic nervierignetes. Direct evidence for a neuropathic etiology comes from studies that show structural changes in autonomic nerve fibers supplying the corpora cavernosa. The present study deals with the post ejaculatory effects of sildenafil citrate (Viagr...

Background: Asymmetrical intrauterine growth restriction IUGR occurs when there is uteroplacental insufficiency. Sildenafil citrate phosphodiasterase-5 inhibito a potent vasodilator, which selectively inhibits phosphodiesterase-5 and, as consequence, enhances the action of cyclic guanosine monophosphate second messenger NO. Hence, trial was used for improving perfusion through enhancing vasodil...

PURPOSE To demonstrate anatomic and physiologic changes in the human choroid following systemic sildenafil citrate (Viagra®) using enhanced depth imaging spectral domain-optical coherence tomography (EDI-OCT) and swept-scan high-frequency digital ultrasound. METHODS Seven healthy male subjects (mean age 32.7 years) were evaluated at baseline and 2 hr after ingesting 50 mg of sildenafil. Swept...