Effective oral delivery of protein and peptide drugs remains an active topic in scientific research. In this study, matrix type microspheres were prepared with Eudragit® L100 containing N-trimethylchitosan chloride to improve the permeation of insulin across the intestinal epithelium via the paracellular pathway. Insulin loaded microspheres were initially formulated in accordance with a factori...

Single molecule DNA experiments often generate data from force versus extension measurements involving the tethering of a microsphere to one end of a single DNA molecule while the other is attached to a substrate. We show that the persistence length of single DNA molecules can also be measured based on the recoil dynamics of these DNA-microsphere complexes if appropriate corrections are made to...

Daytime radiative cooling has attracted considerable attention recently due to its tremendous potential for passively exploiting the coldness of universe as clean and renewable energy. Many advanced materials with novel photonic micro/nanostructures have already been developed enable highly efficient daytime coolers, among which flexible hierarchical porous coatings (HPCs) are a more distinguis...

Light microscopy is one of the most powerful techniques for nondestructive real-time imaging specimens at a resolution beyond reach human eyes. However, spatial any conventional microscope fundamentally limited by diffraction light waves lens aperture. Microsphere-assisted (MAM) has emerged in past decade as an interestingly simple yet efficient method to improve resolution. In MAM, micrometer-...

We present the results of an experiment on measuring gradient Casimir force between Au-coated hollow glass microsphere and graphene-coated fused silica plate by means a modified atomic microscope cantilever-based technique operated in dynamic regime. These measurements were performed high vacuum at room temperature. The energy gap concentration impurities graphene sample used have been measured...

The aim of this study was to evaluate the effect of PLGA microsphere dimensions on bone formation after injection of calcium phosphate cement (CPC)/PLGA in a guinea pig tibial intramedullarly model. To this end, injectable CPC/PLGA formulations were prepared using PLGA microspheres with either a small (~25 µm) or large (~100 µm) diameter, which were incorporated at a 20:80 ratio (wt%) within ap...

ABSTRACr In an open, randomised crossover study enteric coated microspheres of pancreatin were compared with a standard preparation of enteric coated pancreatin over two consecutive 28 day treatment periods in 23 adults with steatorrhoea due to cystic fibrosis. Lipase intake was equal to the patients' previous requirements and was the same during the two months. Patients performed 72 hour faeca...

We investigate the interparticle interactions and phase behavior of microsphere-nanoparticle mixtures of high charge asymmetry and varying size ratio. In the absence of nanoparticles, negligibly charged microspheres flocculate as a result of van der Waals interactions. Upon addition of a lower critical nanoparticle volume fraction, the microspheres are stabilized by the formation of nanoparticl...