Comprehensive mapping of transcription factor binding sites is essential in postgenomic biology. For this, we propose a mining approach combining noisy data from ChIP (chromatin immunoprecipitation)-chip experiments with known binding site patterns. Our method (BoCaTFBS) uses boosted cascades of classifiers for optimum efficiency, in which components are alternating decision trees; it exploits ...

This paper was written to mark the 50th anniversary of Neyman and Scott's Econometrica paper de"ning the incidental parameter problem. It surveys the history both of the paper and of the problem in the statistics and econometrics literature. ( 2000 Elsevier Science S.A. All rights reserved. JEL classixcation: B23; C10

The thanatomicrobiome (thanatos, Greek for death) is a relatively new term and is the study of the microbes colonizing the internal organs and orifices after death. Recent scientific breakthroughs in an initial study of the thanatomicrobiome have revealed that a majority of the microbes within the human body are the obligate anaerobes, Clostridium spp., in the internal postmortem microbial comm...

I am particularly interested in the data published by Brown et al. (2010) in their paper entitled " Vesicular release of gluta-mate utilizes the proton gradient between the vesicle and the synaptic cleft ". The paper presents a decrease in transmitter output when the extracellular pH is acidified. The authors interpret their observation in terms of interference with the pH gradient from the ves...

Cystic fibrosis (CF) was distinguished from celiac disease in 1938. Then, it was a pathologic diagnosis, life expectancy was approximately 6 months, and the autosomal recessive disease was believed to arise from abnormal mucus plugging exocrine ducts. Death often occurred from lung infection. Discovery of the sweat electrolyte defect in 1953 and standardization of the sweat test in 1959 allowed...

Ишемическая болезнь сердца (ИБС) остается главной причиной смерти при сердечно-сосудистых заболеваниях [1]. Внедрение новых технологий (экстренная реваскуляризация миокарда, системный тромболизис) позволило снизить госпитальную летальность у больных с острым инфарктом миокарда, но не повлияло значимо на общую сердечно-сосудистую смертность. Коррекция факторов риска ИБС представляется очень важн...

There are very few reports in regard to relationship between breast size and shoulder-neck pain. The purpose of this study is to examine the correlations among breast size, brassiere cup size, and moment-in-time reporting of shoulderneck pain in a group of adult women. Three hundred thirty nine female volunteers from the hospital staff answered the questionnaire. Breast size, brassiere cup size...

PURPOSE The aim of the current study was to evaluate the efficacy and tolerability of hypo-fractionated whole breast radiation therapy in patients with early breast cancer. METHODS Searching electronically PubMed and the Cochrane Central Register we made a comprehensive literature review regarding the randomized controlled phase III trials for hypo-fractionated radiation therapy in early brea...

Breast pain affects up to 70% of the female population. It is believed that stretching of the breast tissue causes discomfort and that by placing the breast into a position in which the tissue is neither in compression or tension (termed neutral position) will eliminate breast pain. The purpose of the study was to find a simple method that could be used to determine the location of the neutral ...