Abstract Background Mutations in the LMNA gene encoding Lamin A/C, a major component of nuclear lamina, cause laminopathies including dilated cardiomyopathy (DCM). DCM patients with mutations have particularly severe clinical courses such as heart transplantation and death due to failure. However, underlying mechanisms LMNA-induced remains elusive. Methods results We identified Q353R mutation f...

antiproliferative protein (app) isolated from conditioned media of two androgen-independent prostatic carcinoma cell lines, pc3 and du-145 was shown to inhibit selectively cell proliferation of androgen-dependent prostate cancer cell line lncap in a dose dependent manner. this protein was further purified with hplc using hydrophobic interaction column (phenyl 5pw) and was used to study the modu...

Abstract Feed is an important factor affecting the growth of cultured fish. Around 86.5% production cost aquaculture allocated for purchase feed. Good quality and efficient feed a determinant success business. Single Cell Protein (SCP) dry cell product single microorganisms. SCP generally not only protein but also free amino acids, lipids, carbohydrates, vitamins minerals. The purpose this stud...

crystalline arrays of proteinaceous subunits forming surface layers (s-layers) are now recognized as one of the most common outermost cell envelope components of prokaryotic organisms. the surface layer protein of lactobacillus acidophilus atcc4356 is composed of a single species of protein of apparent molecular weight of 43-46 kda. considering the lactobacillus acidophilus atcc4356 having the ...

It has been reported that CXCL12 binding to CXCR4 induces several intracellular signaling pathways, and enhances survival, proliferation, and migration of malignant cells. Herein we examined the effects of anti-estrogen tamoxifen and anti-allergic tranilast drugs as a single or in combination on invasion by two in vitro invasion assays, wound-healing and matrigel invasion on MCF-7 and MDA-MB-23...

Background: Tumor necrosis factor- a (TNF-α) is a cytokine that was identified as a factor with a wide range of proinflammatory activities. The expression of bovine TNF-α in mammary tissue during pregnancy seems to have a role in development of the corresponding glands.Objective: Single nucleotide polymorphisms (SNPs) were defined in 3′-flanking region of...

P48 protein of Mycoplasma agalactiae is used to diagnose infection and was identified as potential vaccine candidate. According to the genetic nature of mycoplasma and variable sensitivity in P48-based serological diagnosis tests, intra species variation of P48 nucleotide sequence investigated in 13 field isolates of difference province of Iran along with three vaccine strains. Samples were col...

a key factor in spermatogenesis and disorders associated with this protein have been recognized to be related to male infertility. although it was suggested that this protein could have different functions during germ cell development, no studies have been conducted to uncover the mechanism of this potential function yet. here, we analyzed the expression pattern of rbmy protein isoforms in test...

On June 30, 2023, the research paper titled "Spatially resolved single-cell translatomics at molecular resolution" published in "SCIENCE" generated significant enthusiasm among biologists. This introduces a novel method and approach for exploring protein synthesis gene expression regulation within cells.