Single motor units were isolated in intact cats, by microstimulation through chronically implanted microwires in the L5 ventral roots. Motor unit axonal and mechanical properties were obtained by stimulus-triggered averaging the signals from an implanted femoral nerve recording cuff and patellar tendon force transducer. All unit types were sampled with this technique, and it was also possible t...

This paper summarizes recent advances of the NeuroProbes project, a 4-year Integrated Project funded by the European Commission under the Information Society Technologies (IST) topic of the 6 Framework Program. NeuroProbes aims at the development of multifunctional probe arrays comprising a 3-dimensional (3D) arrangement of recording and stimulation electrodes in conjunction with microfluidic f...

We present eld potential and multiple single unit data simultaneously recorded from somatosensory cortex of the anesthetized rat using a multi-site silicon electrode. We nd that although single units re spontaneously only during troughs of the low frequency eld potential, there is high variability in the timing of their ring. Viewing our results in the context of previous anatomical, physiologi...

While an electrode has allowed for simultaneously recording the activity of many neurons in microelectrode extracellular recording techniques, quantitative metrics of cluster quality after sorting to identify clusters suited for single unit analysis are lacking. In this paper, an objective measure based on the idea of neighborhood component analysis was described for evaluating cluster quality ...

Dickey AS, Suminski A, Amit Y, Hatsopoulos NG. Single-unit stability using chronically implanted multielectrode arrays. J Neurophysiol 102: 1331–1339, 2009. First published June 17, 2009; doi:10.1152/jn.90920.2008. The use of chronic intracortical multielectrode arrays has become increasingly prevalent in neurophysiological experiments. However, it is not obvious whether neuronal signals obtain...

Brain-machine interfaces (BMIs) hold promise for restoring motor functions in severely paralyzed individuals. Invasive BMIs are capable of recording signals from individual neurons and typically provide the highest signal-to-noise ratio. Despite many efforts in the scientific community, BMI technology is still not reliable enough for widespread clinical application. The most prominent challenge...

We investigated the relevance of single-unit recordings in the context of dynamical neural systems with recurrent synapses. The present study focuses on modeling a relatively small, biologically-plausible network of neurons. In the absence of any input, the network activity is self-sustained due to the resonating properties of the neurons. Recording of single units reveals an increasingly compl...

To study the neurophysiology of large-scale spatial cognition, we analyzed the neuronal activity of navigating homing pigeons. This is not possible using conventional radio-telemetry suitable for short distances only. Therefore we developed a miniaturized data logger ("neurologger") that can be carried by a homing pigeon on its back, in conjunction with a micro-global position system (GPS) logg...

29 Increasing demand exists for smaller multichannel electrodes that enable simultaneous 30 recordings of many neurons in a non-invasive manner. We report a novel method for 31 manufacturing ultra-small carbon fiber electrodes with up to 7 closely spaced recording sites. 32 The electrodes were designed to minimize damage to neuronal circuitry and to be fully 33 customizable in 3D so that their ...