Regulation of the branched chain alpha-ketoacid dehydrogenase complex, the rate-limiting enzyme of branched chain amino acid catabolism, involves phosphorylation of 2 amino acid residues (site 1, serine 293; site 2, serine 303). To directly assess the roles played by these sites, site-directed mutagenesis was used to convert these serines to glutamates and/or alanines. Functional E1 heterotetra...

MicroRNAs (miRNAs) are crucial regulators of gene expression in plants. Here, we performed a comprehensive computational search for novel miRNA--target pairs in rice by a reversed approach. First, the potential cleavage sites in all the 67,392 cDNAs of rice were searched by degradome sequencing datasets. Then, the ‘bait’ sequences, which may be acted as the miRNAs binding sites in the targets, ...

Stability of onand off-site vortex solitons with unit charge in a photorefractive optical lattice is analysed. It is shown that both types of vortex solitons are linearly unstable in the highand low-intensity regimes. In the highintensity regime, the vortex appears as a familiar ring vortex, and it suffers oscillatory instabilities. In the low-intensity regime, the vortex suffers both oscillato...

The objective of this study was to analyze the correlation between lower anterior teeth crowding and the periodontal status among cadets of Armed Forces Institute of Dentistry. The investigation of this relationship was done on 60 cadets. 30 subjects each represented the experimental and the control sample, with an age range between 19-24 years. Plaque Index (PI) of lower six anterior teeth was...

The impact of weed control and fertili7Mion on incnajed tree growth is positive and significant but the effects on wood pmper6es are not well known. lncrernent axes mn, coUac@d from lobldly pine (pinus faeda L) trees growing on an existing site-preparation experiment in the lower Piedmont of Georgia at age 15. The levels of site praparation were: ldearcut only; P-chainsaw, 3-shear and chop; 4-s...

Auditory evoked potentials (AEP) were used to monitor central nervous system effects during induction and recovery from anaesthesia produced by infusion of propofol 30 mg kg-1 h-1 in 22 healthy male patients. Non-parametric and parametric modelling techniques were used successfully to calculate the parameter keo which linked pharmacokinetic with pharmacodynamic aspects of drug action in only 15...

Over the past 15 years, several randomized controlled trials, long-term follow-up studies, meta-analyses, and editorials have been published in regard to the effect of a high fraction of inspired oxygen concentration (FiO(2)) during the perioperative period on the incidence of surgical site infections. Although the evidence is not uniformly favorable for all types of surgeries, a beneficial ass...

Caspases are important mediators of apoptotic cell death. Several cellular protein substrates of caspases contain potential phosphorylation site(s) at the cleavage-site region, and some of these sites have been verified to be phosphorylated. Since phosphorylation may affect substantially the substrate susceptibility towards proteolysis, phosphorylated, non-phosphorylated and substituted oligope...

OBJECTIVES/HYPOTHESIS The aim of this study was to discover the optimal effect-site concentration of remifentanil for cough prevention that does not delay awakening or cause respiratory depression during emergence from anesthesia with propofol and remifentanil in laryngomicrosurgery patients. STUDY DESIGN Prospective, randomized, controlled trial. METHODS One hundred five patients were rand...

In two experiments, the source of competition in the saccadic Stroop effect was investigated. Colored strings of letters were presented at fixation with colored patches in the surround. The task of the participants was to make an eye movement to the patch in the same color as the central string of letters. Three types of cues were compared: Either the string of letters composed a word indicatin...