Entry into mitosis requires the activation of cdk1/cyclin B, while mitotic exit is achieved when the same kinase activity decreases, as cyclin B is degraded. Cyclin B proteolysis is mediated by the anaphase promoting complex, or APC, an E3 ligase that is active at anaphase in mitosis through G1. We have identified a G1 substrate of the APC that we have termed Tome-1, for trigger of mitotic entr...

The electrochemical migration (ECM) behavior of copper-clad laminate (PCB-Cu) and electroless nickel/immersion gold printed circuit boards (PCB-ENIG) under thin electrolyte layers of different thicknesses containing 0.1 M Na₂SO₄ was studied. Results showed that, under the bias voltage of 12 V, the reverse migration of ions occurred. For PCB-Cu, both copper dendrites and sulfate precipitates wer...

SKI-binding protein (SKIP) is a transcription cofactor present in all eukaryotes. Here we show that SKIP is a unique protein that is required for Caenorhabditis elegans viability and development. Expression of CeSKIP (skp-1) assayed by RT-PCR and by GFP fluorescence in transgenic lines starts in embryos and continues to adulthood. Loss of CeSKIP activity by RNA-mediated inhibition results in ea...

bir-1, a Caenorhabditis elegans inhibitor-of-apoptosis gene homologous to Survivin is organized in an operon with the transcription cofactor C. elegans SKIP (skp-1). Because genes arranged in operons are frequently linked functionally, we have asked whether BIR-1 also functions in transcription. bir-1 inhibition resulted in multiple developmental defects that overlapped with C. elegans SKIP los...

Friction stir welding (FSW) is a solid-state joining method that suitable for dissimilar materials such as aluminum and steel due to its comparatively low process temperatures. Such hybrid joints are of great interest in view lightweight construction efforts various industrial sectors transportation. As the combination different metals structures may cause corrosion problems area because format...

Penelitian ini untuk mengetahui, mendeskripsikan dan menganalisis Kebijakan Penilaian Kinerja Pegawai Negeri Sipil Di Badan Kepegawaian Dan Pengembangan Sumber Daya Manusia Kabupaten Minahasa menggunakan metode penelitian kualitatif. Hasil menunjukkan bahwa: 1) Para implementor yang ada di BPKSDM hanya mengetahui secara umum cara dalam peniliaian kinerja PNS. 2) Pimpinan masih kurang pasti pemb...

Capucine Van Rechem, Joshua C. Black, Tarek A. Abbas, Andrew Allen, Claire A. Rinehart, GuoCheng Yuan, Anindya Dutta, and Johnathan R. Whetstine Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, 13 Street, Charlestown, MA 02129, USA. Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22...

In-situ scanning Kelvin probe (SKP) measurements are used to investigate the relative contributions of in-coating zinc (II) cations and phosphate anions inhibition corrosion-driven cathodic disbondment by (ZnPhos) pigments. Using hot-dip galvanized steel (HDG) substrates, delamination rates model polyvinylbutyral (PVB) coatings comprising different pigment volume fractions (?) phosphate-loaded ...