Molecular mechanisms by which the Src homology 2 domain-containing inositol 5-phosphatase (SHIP) negatively regulates phagocytosis in macrophages are unclear. We addressed the issue using bone marrow–derived macrophages from Fc Ror SHIP-deficient mice. Phagocytic activities of macrophages from Fc RII(b) / and SHIP / mice were enhanced to a similar extent, relative to those from wild type. Howev...

Ship grounding is one of the primary maritime navigation casualties and a result of an error made by the navigating officer, of a technical failure on vital ship equipment or of force majeure. In order to decrease the risk of grounding in such cases, this paper explores the ship movement during navigation when an extraordinary event occurs, such as steering system failure that affects the vesse...

With increasing marine transportation and logistics, the ship autopilot has become much more important not only to lower the seaman's operating intensions, but also to reduce the seaman's deployment. It is still a challenge to design ship coursekeeping controller because of ship's uncertain dynamics and time-varying environmental disturbance. This study focuses on backstepping adaptive course-k...

This article explores employee perspectives on effective leader ship in UK Further Education (FE). Studies on leader ship effectiveness typically seek either to specify the individual qualities of ‘heroic’ leaders or, increasingly, to highlight the collective nature of ‘post-heroic’ leader ship. While these discourses are frequently seen as dichotomous and competing, our research found that FE ...

The SH2 domain-containing inositol 5'-phosphatase-1 (SHIP) has the potential to modulate multiple signaling pathways downstream of receptors that impact hematopoietic stem cell (HSC) biology. Therefore, we postulated that SHIP might play an important role in HSC homeostasis and function. Consistent with this hypothesis, HSC proliferation and numbers are increased in SHIP(-/-) mice. Despite expa...

Abstract: Along with increasing marine transportation and logistics, the ship autopilot has become much important not only to lower the seaman's operating intensions, but also to reduce the seaman's deployment. It is still a challenge to design ship course-keeping controller because of ship's uncertain dynamics and time-varying environmental disturbance. This study focuses on backstepping adapt...

In this paper, the characteristics of impact pressure and force a trimaran section was studied by Computational Fluid Dynamics (CFD). The time domain features slamming or showed strong correlation with penetration depth regardless specific ways water entry. effects velocity acceleration on were analyzed. It found that initial main hull wet-deck predominantly affected entry velocities, whilst ha...